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TSLP-mediated fetal B lymphopoiesis?

机译：TSLP介导的胎儿B淋巴细胞生成？

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In the August 2003 issue of Nature Immunology, as well as in later studies, Vosshenrich et al. presented experimental data on the cytokine requirements of developing B cells, which led them to conclude that "TSLP [thymic stromal lymphopoietin] is the factor responsible for most of the fetal and perinatal B cell production that takes place when the IL-7-gammac [interleukin 7-common gamma-chain] signaling pathway is disrupted. Although the data reported were technically sound and compatible with such a conclusion, the authors did not provide direct evidence to support (or exclude) the idea of a critical function for TSLP in IL-7-independent fetal B lymphopoiesis. The conclusions of Vosshenrich et al. were based on the demonstration that B lymphopoiesis was much more affected (tenfold more) in mice deficient in IL-7 receptor alpha-chain, essential for IL-7 as well as TSLP signaling, than in mice deficient in the common gamma-chain (gammac), required for IL-7 but not TSLP-mediated signaling. However, thesedata could at best be considered strong indirect support for the idea of TSLP as the main cytokine driving IL-7-independent fetal B lymphopoiesis, as there could be other reasons for a difference in the phenotypes of gammac-deficient mice and those deficient in the IL-7 receptor alpha-chain. Furthermore, Vosshenrich et al. used bone marrow of mice 4-12 weeks of age, not fetal liver, for their comparative in vivo analysis of B lymphopoiesis in these mice. Instead, the extrapolation to the idea that TSLP is key to the fetal stages of B lymphopoiesis was based on the finding that fetal but not adult pro-B cells were responsive to TSLP in vitro. In contrast, a lack of an important function for TSLP in adult B lymphopoiesis has been indicated by studies of TSLP receptor-deficient (Tpte2~(-/-)) mice.
机译：在2003年8月出版的《自然免疫学》以及后来的研究中，Vosshenrich等人。提出了有关发育中的B细胞所需细胞因子的实验数据，这使他们得出结论：“ TSLP [胸腺基质淋巴细胞生成素]是导致大多数胎儿和围产期B细胞产生的因素，IL-7-gammac [尽管报告的数据在技术上是合理的，并且与上述结论兼容，但作者并未提供直接的证据来支持（或排除）IL的TSLP关键功能的想法不依赖-7的胎儿B淋巴细胞生成Vosshenrich等人的结论基于以下事实：在缺乏IL-7受体α链的小鼠中，B淋巴细胞生成受到的影响更大（十倍），这对IL-7也是必不可少的作为TSLP信号转导，比IL-7所必需的缺乏通用γ链（gammac）的小鼠（而不是TSLP介导的信号转导），这些数据充其量可以被认为是对TSLP观点的间接支持作为导致非IL-7依赖的胎儿B淋巴细胞生成的主要细胞因子，因为有gamgam缺陷小鼠和IL-7受体α链缺陷小鼠的表型可能存在其他原因。此外，Vosshenrich等。使用了4-12周龄小鼠而非胎儿肝脏的骨髓进行了体内B淋巴细胞生成的比较分析。取而代之的是，TSLP是B淋巴细胞生成的胎儿阶段的关键这一思想的推断是基于这样的发现：在体外，胎儿而非成人的pro-B细胞对TSLP有反应。相反，对TSLP受体缺陷型（Tpte2〜（-/-））小鼠的研究表明，在成年B淋巴细胞生成中TSLP缺乏重要功能。

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