Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

Johnson AL; Aravind L; Shulzhenko N

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Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

机译：Themis是新的后生动物基因家族的成员，是完成胸腺细胞阳性选择所必需的。

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T cell antigen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem repeat of a unique globular domain (called 'CABIT' here) that includes a cysteine motif that defines a family of five uncharacterized vertebrate proteins with orthologs in most animal species. Themis-deficient thymocytes showed no substantial impairment in early TCR signaling but did show altered expression of genes involved in the cell cycle and survival before and during positive selection. Our data suggest a unique function for Themis in sustaining positive selection.

机译：CD4（+）CD8（+）双阳性胸腺细胞中的T细胞抗原受体（TCR）信号决定细胞存活和谱系承诺，但此过程的遗传和分子基础定义不清。为了解决这个问题，我们使用乙基亚硝基脲诱变来鉴定以前未知的T谱系特异性基因Themis，这对于完成阳性选择至关重要。 Themis包含一个独特的球形结构域的串联重复序列（此处称为“ CABIT”），该结构域包含一个半胱氨酸基序，该基序定义了五个未表征的脊椎动物蛋白家族，在大多数动物物种中都具有直系同源物。缺乏mis的胸腺细胞在早期TCR信号转导中没有实质性的损害，但是在阳性选择之前和之中确实显示了参与细胞周期和存活的基因表达的改变。我们的数据表明Themis在维持积极选择方面具有独特的功能。

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《Nature immunology》 |2009年第8期|共9页
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Johnson AL; Aravind L; Shulzhenko N;
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1. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. [J] . Johnson AL, Aravind L, Shulzhenko N Nature immunology . 2009,第8期

机译：Themis是新的后生动物基因家族的成员，是完成胸腺细胞阳性选择所必需的。
2. Themis imposes new law and order on positive selection. [J] . Allen PM Nature immunology . 2009,第8期

机译：mis弥斯对积极选择施加了新的法律和秩序。
3. Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. [J] . Paschalidis N, Huggins A, Rowbotham NJ, Cell cycle . 2010,第4期

机译：内源性膜联蛋白-A1在胸腺细胞正负选择调控中的作用。
4. Evolutionary Dynamics in the Aphid Genome: Search for Genes Under Positive Selection and Detection of Gene Family Expansions [C] . Morgane Ollivier, Claude Rispe Evolutionary Biology Meeting . 2011

机译：蚜虫基因组中的进化动态：在阳性选择和检测基因家族扩张下搜索基因
5. The molecular mechanism of Nur77/Nor-1 induced apoptosis of thymocytes undergoing negative selection. [D] . Thompson, Jennifer. 2009

机译：Nur77 / Nor-1诱导经历负选择的胸腺细胞凋亡的分子机制。
6. Themis is a member of a new metazoan gene family and is required for completion of thymocyte positive selection [O] . Andy L. Johnson, L. Aravind, Natalia Shulzhenko, -1

机译：Themis是新的Metazoan基因家族的成员并且需要完成胸腺细胞阳性选择
7. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. [O] . Johnson AL, Aravind L, Shulzhenko N, 2010

机译：Themis是新的后生动物基因家族的成员，是完成胸腺细胞阳性选择的必需条件。

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

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