Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A

Dennis W. Wolan; Luc Teyton; Markus G. Rudolph; Brigitte Villmow; Stefan Bauer; Dirk H. Busch; Ian A. Wilson

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Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A

机译：小鼠NK细胞激活受体NKG2D在1.95 A处的晶体结构

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NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells, T cells and activated macrophages. The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties. The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.

机译：NKG2D是一种同型二聚凝集素样受体，是一种独特的刺激性分子，存在于自然杀伤细胞，T细胞和活化的巨噬细胞上。鼠NKG2D的天然配体是遥远的主要组织相容性复合物同源物，视黄酸早期转录本（Rae1）和H-60较小的组织相容性抗原。鼠NKG2D胞外区的晶体结构显示出与其他C型凝集素受体如CD94，Ly49A，大鼠MBP-A和CD69的紧密同源性。但是，二聚体组装的精确模式在这些自然杀伤受体之间以及它们的表面形貌和静电性质方面有所不同。 NKG2D结构提供了对这种刺激性受体在先天和适应性免疫系统中的作用和配体特异性的第一结构见解。

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《Nature immunology》 |2001年第3期|共7页
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Dennis W. Wolan; Luc Teyton; Markus G. Rudolph; Brigitte Villmow; Stefan Bauer; Dirk H. Busch; Ian A. Wilson;
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1. Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A [J] . Dennis W. Wolan, Luc Teyton, Markus G. Rudolph, Nature immunology . 2001,第3期

机译：小鼠NK细胞激活受体NKG2D在1.95 A处的晶体结构
2. Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D. [J] . Li Pingwei, McDermott Gerry, Strong RolandK Immunity . 2002,第1期

机译：RAE-1beta的晶体结构及其与活化免疫受体NKG2D的复合物。
3. Efficient Killing of Murine Pluripotent Stem Cells by Natural Killer (NK) Cells Requires Activation by Cytokines and Partly Depends on the Activating NK Receptor NKG2D [J] . Gr?schel, Carina Frontiers in Immunology . 2017,第4期

机译：自然杀伤（NK）细胞有效杀死小鼠多能干细胞需要细胞因子激活，部分取决于激活的NK受体NKG2D
4. Expressions Levels of TGF-betal,FGF2 and their Receptors in Murine Cranial Sutures Analyzed by Keal Time RT-PCR [C] . A.K. GOSAIN, R. SCHAEFE International Society of Craniofacial Surgery . 2005

机译：通过Keal TimeTT-PCR分析的鼠颅缝中TGF-β，FGF2及其受体的表达水平
5. Regulation and genetic manipulation of ligands for the immunoreceptor NKG2D. [D] . Gowen, Benjamin Gregory. 2015

机译：免疫受体NKG2D配体的调控和遗传操作。
6. Natural Killer Cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts [O] . Lori K. Phillips, Elizabeth A. Gould, Harish Babu, -1

机译：自然杀伤细胞激活受体NKG2D介导同种异体神经祖细胞移植物的先天免疫靶向。
7. Natural killer cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts [O] . Lori K. Phillips, Elizabeth A. Gould, Harish Babu, 2013

机译：天然杀手细胞活化受体NKG2D介导同种异体神经祖细胞移植物的先天免疫靶向
8. Evidence of NK1 and NK2 Tachykinin Receptors and their Involvement in HistamineRelease in a Murine Mast Cell Line [R] . Krumins, S. A., Broomfield, C. A. 1992

机译：NK1和NK2速激肽受体的证据及其在小鼠肥大细胞系中对组胺释放的参与

Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A

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