...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature immunology >DNA polymerase-alpha regulates the activation of type I interferons through cytosolic RNA:DNA synthesis
【24h】

DNA polymerase-alpha regulates the activation of type I interferons through cytosolic RNA:DNA synthesis

机译：DNA聚合酶-α通过细胞溶质RNA调节I型干扰素的激活：DNA合成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aberrant nucleic acids generated during viral replication are the main trigger for antiviral immunity, and mutations that disrupt nucleic acid metabolism can lead to autoinflammatory disorders. Here we investigated the etiology of X-linked reticulate pigmentary disorder (XLPDR), a primary immunodeficiency with autoinflammatory features. We discovered that XLPDR is caused by an intronic mutation that disrupts the expression of POLA1, which encodes the catalytic subunit of DNA polymerase-alpha. Unexpectedly, POLA1 deficiency resulted in increased production of type I interferons. This enzyme is necessary for the synthesis of RNA: DNA primers during DNA replication and, strikingly, we found that POLA1 is also required for the synthesis of cytosolic RNA: DNA, which directly modulates interferon activation. Together this work identifies POLA1 as a critical regulator of the type I interferon response.
机译：病毒复制过程中产生的异常核酸是抗病毒免疫的主要诱因，破坏核酸代谢的突变会导致自身炎症。在这里，我们调查了X连锁网状色素性疾病（XLPDR）的病因，这是一种具有自身炎症特征的主要免疫缺陷。我们发现XLPDR是由内含子突变引起的，该突变破坏了POLA1的表达，该POLA1编码DNA聚合酶α的催化亚基。出乎意料的是，POLA1缺乏导致I型干扰素产生增加。该酶对于DNA复制过程中RNA：DNA引物的合成是必不可少的，而且令人惊讶的是，我们发现POLA1也是直接调节干扰素活化的胞质RNA：DNA合成所必需的。这项工作共同确定了POLA1是I型干扰素反应的关键调节剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号