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首页> 外文期刊>Nature clinical practice. Cardiovascular medicine >Adverse cardiovascular effects of air pollution.
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Adverse cardiovascular effects of air pollution.

机译：空气污染对心血管的不良影响。

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摘要

Air pollution is increasingly recognized as an important and modifiable determinant of cardiovascular disease in urban communities. Acute exposure has been linked to a range of adverse cardiovascular events including hospital admissions with angina, myocardial infarction, and heart failure. Long-term exposure increases an individual's lifetime risk of death from coronary heart disease. The main arbiter of these adverse health effects seems to be combustion-derived nanoparticles that incorporate reactive organic and transition metal components. Inhalation of this particulate matter leads to pulmonary inflammation with secondary systemic effects or, after translocation from the lung into the circulation, to direct toxic cardiovascular effects. Through the induction of cellular oxidative stress and proinflammatory pathways, particulate matter augments the development and progression of atherosclerosis via detrimental effects on platelets, vascular tissue, and the myocardium. These effects seem to underpinthe atherothrombotic consequences of acute and chronic exposure to air pollution. An increased understanding of the mediators and mechanisms of these processes is necessary if we are to develop strategies to protect individuals at risk and reduce the effect of air pollution on cardiovascular disease.
机译：在城市社区，空气污染日益被认为是心血管疾病的重要且可改变的决定因素。急性暴露已与一系列不良心血管事件相关，包括因心绞痛住院，心肌梗塞和心力衰竭。长期接触会增加一生中因冠心病死亡的风险。这些不良健康影响的主要仲裁者似乎是燃烧衍生的纳米粒子，其中包含反应性有机和过渡金属成分。吸入这种颗粒物会导致肺部发炎，继发全身性作用，或者在从肺部转移到循环系统后直接导致有毒的心血管作用。通过诱导细胞氧化应激和促炎途径，颗粒物质通过对血小板，血管组织和心肌的有害作用来增强动脉粥样硬化的发展和进程。这些影响似乎是急性和慢性暴露于空气污染的血栓形成后果的基础。如果我们要制定策略来保护处于危险之中的个人并减少空气污染对心血管疾病的影响，则必须对这些过程的介质和机制有更多的了解。

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