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首页> 外文期刊>Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association >Prevalence and severity of oral disease in adults with chronic kidney disease: A systematic review of observational studies
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Prevalence and severity of oral disease in adults with chronic kidney disease: A systematic review of observational studies

机译：成人慢性肾脏病患者口腔疾病的患病率和严重性：观察性研究的系统综述

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Background. Oral disease may be increased in people with chronic kidney disease (CKD) and, due to associations with inflammation and malnutrition, represents a potential modifiable risk factor for cardiovascular disease and mortality. We summarized the prevalence of oral disease in adults with CKD and explored any association between oral disease and mortality. Methods. We used systematic review of observational studies evaluating oral health in adults with CKD identified in MEDLINE (through September 2012) without language restriction. We summarized prevalence and associations with all-cause and cardiovascular mortality using random-effects meta-analysis. We explored for sources of heterogeneity between studies using meta-regression. Results. Eighty-eight studies in 125 populations comprising 11 340 adults were eligible. Edentulism affected one in five adults with CKD Stage 5D (dialysis) {20.6% [95% confidence interval (CI), 16.4-25.6]}. Periodontitis was more common in CKD Stage 5D [56.8% (CI, 39.3-72.8)] than less severe CKD [31.6% (CI, 19.0-47.6)], although data linking periodontitis with premature death were scant. One-quarter of patients with CKD Stage 5D reported never brushing their teeth [25.6% (CI, 10.2-51.1)] and a minority used dental floss [11.4% (CI, 6.2-19.8)]; oral pain was reported by one-sixth [18.7% (CI, 8.8-35.4)], while half of patients experienced a dry mouth [48.4% (CI, 37.5-59.5)]. Data for kidney transplant recipients and CKD Stages 1-5 were limited. Conclusions. Oral disease is common in adults with CKD, potentially reflects low use of preventative dental services, and may be an important determinant of health in this clinical setting.
机译：背景。患有慢性肾脏病（CKD）的人的口腔疾病可能会增加，并且由于与炎症和营养不良有关，是心血管疾病和死亡率的潜在可改变危险因素。我们总结了CKD成人口腔疾病的患病率，并探讨了口腔疾病与死亡率之间的任何关联。方法。我们使用观察性研究的系统评价，评估了在MEDLINE中（截至2012年9月）不受语言限制的成人CKD的口腔健康状况。我们使用随机效应荟萃分析总结了患病率及其与全因和心血管疾病死亡率的关系。我们探索了使用元回归研究之间异质性的来源。结果。在125个人群中进行的88项研究（包括11340名成年人）符合条件。偏执狂影响了CKD 5D期（透析）成人的五分之一{20.6％[95％置信区间（CI），16.4-25.6]}。尽管很少有将牙周炎与过早死亡联系起来的数据，但CKD 5D期的牙周炎[56.8％（CI，39.3-72.8）]比轻度的CKD [31.6％（CI，19.0-47.6）]更常见。四分之一的CKD 5D期患者报告从未刷牙[25.6％（CI，10.2-51.1）]，少数人使用牙线[11.4％（CI，6.2-19.8）];六分之一的人报告了口腔疼痛[18.7％（CI，8.8-35.4）]，而一半的患者出现口干[48.4％（CI，37.5-59.5）]。肾脏移植接受者和CKD 1-5期的数据有限。结论。口腔疾病在CKD成人中很常见，可能反映出预防性牙科服务使用率低，并且可能是这种临床环境下健康的重要决定因素。

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