• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature reviews. Urology >Prostate cancer in young men: An important clinical entity
【24h】

Prostate cancer in young men: An important clinical entity

机译：年轻人前列腺癌：重要的临床实体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prostate cancer is considered a disease of older men (aged >65 years), but today over 10% of new diagnoses in the USA occur in young men aged ≤55 years. Early-onset prostate cancer, that is prostate cancer diagnosed at age ≤55 years, differs from prostate cancer diagnosed at an older age in several ways. Firstly, among men with high-grade and advanced-stage prostate cancer, those diagnosed at a young age have a higher cause-specific mortality than men diagnosed at an older age, except those over age 80 years. This finding suggests that important biological differences exist between early-onset prostate cancer and late-onset disease. Secondly, early-onset prostate cancer has a strong genetic component, which indicates that young men with prostate cancer could benefit from evaluation of genetic risk. Furthermore, although the majority of men with early-onset prostate cancer are diagnosed with low-risk disease, the extended life expectancy of these patients exposes them to long-term effects of treatment-related morbidities and to long-term risk of disease progression leading to death from prostate cancer. For these reasons, patients with early-onset prostate cancer pose unique challenges, as well as opportunities, for both research and clinical communities. Current data suggest that early-onset prostate cancer is a distinct phenotype - from both an aetiological and clinical perspective - that deserves further attention.
机译：前列腺癌被认为是老年男性（> 65岁）的疾病，但如今，美国超过10％的新诊断发生在55岁以下的年轻男性中。早发性前列腺癌，即≤55岁被诊断为前列腺癌，在几方面与老年时被诊断为前列腺癌。首先，在患有高级和晚期前列腺癌的男性中，除80岁以上的男性外，与年龄较大的男性相比，年轻的男性具有更高的因因死亡率。这一发现表明，早发性前列腺癌和晚发性疾病之间存在重要的生物学差异。其次，早发性前列腺癌具有很强的遗传成分，这表明患有前列腺癌的年轻男性可以从遗传风险评估中受益。此外，尽管大多数患有早发性前列腺癌的男性被诊断出患有低危疾病，但这些患者的预期寿命延长使他们面临与治疗相关的疾病的长期影响以及长期疾病进展的风险。死于前列腺癌。由于这些原因，患有早发性前列腺癌的患者给研究和临床社区带来了独特的挑战和机遇。目前的数据表明，从病因学和临床角度来看，早发型前列腺癌是一种独特的表型，值得进一步关注。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号