...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature structural biology >A collapsed non-native RNA folding state
【24h】

A collapsed non-native RNA folding state

机译：折叠的非天然RNA折叠状态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

At physiological Mg2+ concentrations, the catalytic core of the bI5 group I intron does not fold into its native structure, In contrast, as judged by the global size, this RNA undergoes structural collapse at Mg2+ concentrations much lower than required to drive folding of the RNA completely to the native state. The bI5 RNA therefore exists in equilibrium between expanded and collapsed non-native states. The activation energy of RNA folding from the collapsed state to the native state is negligible and the reaction is not accelerated by the addition of urea. This collapsed state is thus distinct from the kinetic traps observed during folding of other large RNAs, The collapsed non-native state forms readily in the case of bI5 RNA and may exist generically prior to assembly of other ribonucleoprotein holoenzymes, such as the ribosome. [References: 41]
机译：在生理Mg2 +浓度下，bI5组I内含子的催化核心不会折叠成其天然结构。相反，根据整体大小判断，此RNA在Mg2 +浓度下发生的结构折叠远低于驱动RNA折叠所需的水平完全恢复到原始状态。因此，bI5 RNA在膨胀和折叠非天然状态之间处于平衡状态。从折叠状态折叠到天然状态的RNA的活化能可忽略不计，并且反应不会因添加尿素而加速。因此，这种折叠状态与其他大RNA折叠过程中观察到的动力学陷阱不同。在bI5 RNA的情况下，折叠非天然状态很容易形成，并且可能在组装其他核糖核蛋白全酶（如核糖体）之前普遍存在。 [参考：41]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号