Potentiation by calcium ions of (3H)MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.

Han D; Ogita K; Yoneda Y

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Potentiation by calcium ions of (3H)MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.

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Potentiation by calcium ions of (3H)MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.

机译：（3H）MK-801的钙离子与大鼠脑中N-甲基-D-天冬氨酸受体复合物相关的离子通道结合后的增强作用。

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In vitro addition of Ca2+ ions was effective in almost doubling binding of [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imi ne (MK-801) before equilibrium to an ion channel associated with an N-methyl-D-aspartate (NMDA)-sensitive subclass of brain excitatory amino acid receptors. The addition of inhibitors for phospholipase (PLase) A2 markedly reduced binding in the absence of added Ca2+ ions, while Ca2+ ions restored the reduction to the level found in the absence of the inhibitors. Pretreatment with PLases A2 and C but not D was effective in potentiating [3H]MK-801 binding in a biphasic manner at a concentration range of 5 mU/ml-10 U/ml. Moreover, PLases A2 and C at low concentrations not only suppressed the abilities of 3 different agonists to potentiate [3H]MK-801 binding before equilibrium, but also reduced that of Ca2+ ions. These results suggest that Ca2+ ions may potentiate [3H]MK-801 binding to the NMDA channel highly permeable to Ca2+ ions through a mechanism common to that underlying potentiation by exogenous PLase A2 and/or C.

机译：体外添加Ca2 +离子可有效地使[3H]（+）-5-甲基-10,11-二氢-5H-二苯并[a，d]环庚烯5,10-亚胺的结合几乎翻倍（MK-801 ）平衡至与脑兴奋性氨基酸受体的N-甲基-D-天冬氨酸（NMDA）敏感亚类相关的离子通道之前。在不存在添加的Ca2 +离子的情况下，添加磷脂酶（PLase）A2抑制剂会显着降低结合，而Ca2 +离子可将还原恢复到在不存在抑制剂的情况下的水平。用PLase A2和C预处理但不使用D预处理可以有效地以双相方式在5 mU / ml-10 U / ml的浓度范围内增强[3H] MK-801的结合。此外，低浓度的PLase A2和C酶不仅抑制了3种不同激动剂在平衡前增强[3H] MK-801结合的能力，还降低了Ca2 +离子的能力。这些结果表明，Ca2 +离子可能通过与外源PLase A2和/或C潜在的增效作用共有的机制，增强[3H] MK-801与Ca2 +离子高度可渗透的NMDA通道的结合。

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来源
《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |1995年第1期|共10页
作者
Han D; Ogita K; Yoneda Y;
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正文语种 eng
中图分类生物化学;
关键词
Calcium; Dizocilpine Maleate; Ion Channels; Receptors; N-Methyl-D-Aspartate; 钙; 地卓西平马来酸盐; 离子通道; 受体; N-甲基-D-天冬氨酸;

机译：Calcium;Dizocilpine Maleate;Ion Channels;Receptors;N-Methyl-D-Aspartate;钙;地卓西平马来酸盐;离子通道;受体;N-甲基-D-天冬氨酸;

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1. Potentiation by calcium ions of (3H)MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain. [J] . Han D, Ogita K, Yoneda Y Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 1995,第1期

机译：（3H）MK-801的钙离子与大鼠脑中N-甲基-D-天冬氨酸受体复合物相关的离子通道结合后的增强作用。
2. Polyamine and redox modulation of (3H)MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex. [J] . Sundstrom E, Mo LL Pharmacology and Toxicology: An International Journal . 2001,第6期

机译：（3H）MK-801与脊髓和大脑皮层中N-甲基-D-天冬氨酸受体结合的多胺和氧化还原调节。
3. Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of (3H)MK-801 to NMDA receptors in the dopaminergic structures of the rat brain. [J] . Lorenc Koci E, Golembiowska K, Pietraszek M, Pharmacological reports: PR . 2009,第5期

机译：用1,2,3,4，-四氢异喹啉处理会影响纹状体中的谷氨酸释放，但不会影响（3H）MK-801与大鼠脑多巴胺能结构中NMDA受体的结合。
4. N-Methyl-D-Aspartate Receptor Channels Influence Dendritic Calcium Signaling in Nucleus Accumbens Medium Spiny Neurons - A Computational Study [C] . J. John, R. Manchanda World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：N-甲基-D-天冬氨酸受体通道影响伏隔核中棘神经元中的树突钙信号传导-计算研究
5. Effect of chronic ethanol exposure on the expression of the N-methyl-D-aspartate (NMDA) receptor 2C subunit and on MK-801 binding sites in the cerebral cortex of the near-term fetal guinea pig. [D] . Chiu, Joanne Wing-Yan. 1997

机译：长期乙醇暴露对近期胎鼠豚鼠大脑皮层N-甲基-D-天冬氨酸（NMDA）受体2C亚单位表达和MK-801结合位点的影响。
6. Interaction of [3H]MK-801 with multiple states of the N-methyl-D-aspartate receptor complex of rat brain. [O] . D C Javitt, S R Zukin 2017

机译：[3H] MK-801与大鼠脑N-甲基-D-天冬氨酸受体复合物的多种状态的相互作用。
7. Interaction of [3H]MK-801 with multiple states of the N-methyl-D-aspartate receptor complex of rat brain. [O] . Javitt, D C, Zukin, S R 1989

机译：[3H] MK-801与大鼠脑N-甲基-D-天冬氨酸受体复合物的多种状态的相互作用。
8. Persistent Increase of Hippocampal Presynaptic Axon Excitability After RepetitiveElectrical Stimulation: Dependence on N-Methyl-D-Aspartate Receptor Activity, Nitric-Oxide Synthase, and Temperature, (Quantal Analysts/Long-Term Potentiation/Neurophysiology [R] . McNaughton, B. L., Shen, J., Rao, G., 1994

机译：海马突触前轴突兴奋性持续上升RepetitiveElectrical刺激后：依赖是N-甲基d天冬氨酸受体活性，一氧化氮合酶，和温度（量子理论分析/长时程增强/神经生理学

Potentiation by calcium ions of (3H)MK-801 binding to an ion channel associated with the N-methyl-D-aspartate receptor complex in rat brain.

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