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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >White matter lesions and soluble interleukin-1 receptor type II in CSF from demented and non-demented subjects.
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White matter lesions and soluble interleukin-1 receptor type II in CSF from demented and non-demented subjects.

机译：痴呆和非痴呆受试者的CSF中的白质损伤和可溶性II型白介素-1受体。

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摘要

White matter lesions (WMLs) in the brain is a common, unspecific finding on magnetic resonance imaging appearing both in the healthy elderly as well as in a number of different diseases including dementia disorders. However, the pathophysiological and clinical significance of WMLs in dementia disorders is still unknown. In this study, we investigated the possibility of their origin being inflammatory by studying the correlation between WMLs and cerebrospinal fluid (CSF) levels of the proinflammatory cytokine soluble interleukin-1 receptor type II (sIL-1RII). The sIL-1RII is a member of the IL-1 family, and has been found to be elevated in CSF from Alzheimer's disease (AD) patients. In the present study, two groups of patients complaining of memory disturbances with little or extensive WMLs respectively, were examined, as well as healthy subjects. In accordance with other reports, WML scores (total, periventricular as well as deep lesions) were positively correlated with age but not mini mental state examination (MMSE) scores, and were significantly higher in patients with a dementia diagnosis as compared to non-demented subjects. There were no differences in sIL-1RII levels in CSF regardless of amount of total, periventricular or deep WMLs, nor were there any differences between demented and non-demented subjects. In conclusion, sIL-1RII levels in CSF are not correlated to magnetic resonance imaging WMLs in patients with dementia disorders or in healthy subjects.
机译：大脑中的白质损伤（WML）是磁共振成像中常见的，非特异性的发现，既出现在健康的老年人中，也出现在包括痴呆症在内的许多不同疾病中。但是，WML在痴呆症中的病理生理和临床意义仍然未知。在这项研究中，我们通过研究WML与II型促炎性细胞因子可溶性白介素1受体（sIL-1RII）的脑脊液（CSF）水平之间的相关性，研究了它们起源于炎症的可能性。 sIL-1RII是IL-1家族的成员，并且已发现阿尔茨海默氏病（AD）患者的CSF升高。在本研究中，检查了两组抱怨记忆障碍的患者，分别患有少量或广泛的WML，以及健康受试者。根据其他报告，WML评分（总，脑室周围以及深部病变）与年龄呈正相关，但与轻度精神状态检查（MMSE）得分无关，并且与非痴呆患者相比，患有痴呆症的患者明显更高科目。无论总脑室，室周或深部WML的量如何，CSF的sIL-1RII水平均无差异，痴呆和非痴呆受试者之间也无任何差异。总之，在痴呆症患者或健康受试者中，CSF中的sIL-1RII水平与磁共振成像WML无关。

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