Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.

Taneichi Kuroda S; Taya S; Hikita T

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.

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Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.

机译：Dysbindin通过其mu亚基与AP-3复合物的直接相互作用。

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Genetic factors are important in the etiology of schizophrenia. Recent studies have revealed the association between genetic variation of Dysbindin (DTNBP1) and schizophrenia. Dysbindin is one of the essential components of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). BLOC-1 physically interacts with the adaptor protein (AP)-3 complex, which is essential for vesicle or protein sorting. However, it remains largely unknown how BLOC-1 interacts with the AP-3 complex. To investigate the binding mode of BLOC-1 and the AP-3 complex, we examined the relation between Dysbindin and the AP-3 complex and found that Dysbindin formed a complex with the AP-3 complex through the direct binding to its mu subunit. Dysbindin partially co-localized with the AP-3 complex in CA1 and CA3 of mouse hippocampus, and at presynaptic terminals and axonal growth cones of cultured hippocampal neurons. Suppression of Dysbindin results in the reduction of presynaptic protein expression and glutamate release. Thus, Dysbindin appears to participate in the exocytosis or sorting of the synaptic vesicle via direct interaction with the AP-3 complex.

机译：遗传因素在精神分裂症的病因中很重要。最近的研究表明Dysbindin（DTNBP1）的遗传变异与精神分裂症之间的关联。 dysbindin是溶酶体相关细胞器复合物1（BLOC-1）的生物合成的重要组成部分之一。 BLOC-1与衔接蛋白（AP）-3复合物发生物理相互作用，这对于囊泡或蛋白质分选至关重要。但是，很大程度上尚不清楚BLOC-1如何与AP-3复合体相互作用。为了研究BLOC-1与AP-3复合物的结合方式，我们检查了Dysbindin与AP-3复合物之间的关系，发现Dysbindin通过直接与其μ亚基结合而与AP-3复合物形成复合物。 Dysbindin与AP-3复合体在小鼠海马CA1和CA3中以及在培养的海马神经元的突触前末端和轴突生长锥中部分共定位。 Dysbindin的抑制导致突触前蛋白表达和谷氨酸释放的减少。因此，Dysbindin似乎通过与AP-3复合物的直接相互作用而参与了突触小泡的胞吐作用或分选。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2009年第7期|共8页
作者
Taneichi Kuroda S; Taya S; Hikita T;
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中图分类生物化学;
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1. Direct interaction of Dysbindin with the AP-3 complex via its mu subunit. [J] . Taneichi Kuroda S, Taya S, Hikita T Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2009,第7期

机译：Dysbindin通过其mu亚基与AP-3复合物的直接相互作用。
2. Genomic organization and linkage via a bidirectional promoter of the AP-3 (adaptor protein-3) mu 3A and AK (adenosine kinase) genes: deletion mutants of AK in Chinese hamster cells extend into the AP-3 mu 3A gene [J] . Singh B, Gupta RS The Biochemical Journal . 2004,第Pta2期

机译：基因组的组织和通过AP-3（适配器蛋白3）mu 3A和AK（腺苷激酶）基因的双向启动子进行连接：中国仓鼠细胞中AK的缺失突变体延伸到AP-3 mu 3A基因中
3. [Pb_2(2,2'-bipy)_2(mu-4,4'-bipy)(NO_3)_4]:A novel hemidirected dimeric mixed-ligands lead(II) complex extended in holodirected two-dimensional polymer by weak Pb-O_(nitrate) interactions [J] . All Akbar Soudi, Farzin Marandi, All Morsali, Inorganic Chemistry Communications . 2005,第9期

机译：[Pb_2（2,2'-bipy）_2（mu-4,4'-bipy）（NO_3）_4]：新型半定向二聚体混合配体铅（II）络合物，通过弱Pb-在全向二维聚合物中延伸O_（硝酸盐）相互作用
4. EPR Studies and Ferromagnetic Interaction of a Dinuclear Copper Complex Mediated by mu-1,1 Bridging Azido Group of the Ligand Hsalamp [C] . R. Srinivasan, B. Natarajan, R. Venkatesan Asia-Pacific EPR/ESR Symposium . 2006

机译：通过MU-1,1桥接氮杂铜铜介导的二核铜复合物的EPR研究和铁磁性相互作用的配体Hsalamp
5. Investigation of copper(II) complexes: I. Copper(II) complexes of tryptophan and its analogues as postcolumn interaction components for indirect fluorescence detection of amino-containing analytes. II. High-performance liquid chromatographic separation of copper(II) azamacrocyclic complexes. [D] . Shen, Xiaoxuan. 2006

机译：铜（II）配合物的研究：I.色氨酸及其类似物作为柱后相互作用组分的铜（II）配合物，用于间接荧光检测含氨基的分析物。二。铜（II）氮杂大环配合物的高效液相色谱分离。
6. Genomic organization and linkage via a bidirectional promoter of the AP-3 (adaptor protein-3) mu3A and AK (adenosine kinase) genes: deletion mutants of AK in Chinese hamster cells extend into the AP-3 mu3A gene. [O] . Bhag Singh, Radhey S Gupta 2004

机译：基因组的组织和通过AP-3（衔接蛋白3）mu3A和AK（腺苷激酶）基因的双向启动子进行连接：中国仓鼠细胞中AK的缺失突变体延伸到AP-3 mu3A基因中。
7. Genomic organization and linkage via a bidirectional promoter of the AP-3 (adaptor protein-3) mu3A and AK (adenosine kinase) genes: deletion mutants of AK in Chinese hamster cells extend into the AP-3 mu3A gene. [O] . Singh, Bhag, Gupta, Radhey S 2004

机译：基因组的组织和通过AP-3（衔接蛋白3）mu3A和AK（腺苷激酶）基因的双向启动子进行连接：中国仓鼠细胞中AK的缺失突变体延伸到AP-3 mu3A基因中。
8. Chemistry of Polynuclear Metal Complexes with Bridging Carbene or Carbyne Ligands. Part 89. (1) Tetra- and Penta-nuclear Tungsten-Rhodium Complexes: Crystal Structures of (W3Rh2(mu-CO)2(mu-CMe)(mu-C(Me)C(O))(Mu-PPh2)2-(Mu3-CMe)(CO)2(eta- C5H5)3) and (W3Rh2(mu-CO)3(mu-CMe)(mu-C(Me)PPh2)(mu3-CMe)-(CO)2(mu-C5H5)3). [R] . Davies, S. J., Stone, F. G., Howard, J. A., 1989

机译：具有桥接卡宾或卡宾配体的多核金属配合物的化学。第89部分。（1）四核和五核钨铑配合物：（W3Rh2（mu-CO）2（mu-Cme）（μ-C（me）C（O））（mu-pph2）的晶体结构2-（mu3-Cme）（CO）2（eta-C5H5）3）和（W3Rh2（mu-CO）3（mu-Cme）（μ-C（me）pph2）（mu3-Cme） - （CO） 2（mU-C5H5）3）。

Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.

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