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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion
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Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion

机译：铁超负荷（以血清铁蛋白计）可增加局灶性局部缺血和早期再灌注引起的脑损伤

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摘要

High levels of iron, measured as serum ferritin, are associated to a worse outcome after stroke. However, it is not known whether ischemic damage might increase ferritin levels as an acute phase protein or whether iron overload affects stroke outcome. The objectives are to study the effect of stroke on serum ferritin and the contribution of iron overload to ischemic damage. Swiss mice were fed with a standard diet or with a diet supplemented with 2.5% carbonyl iron to produce iron overload. Mice were submitted to permanent (by ligature and by in situ thromboembolic models) or transient focal ischemia (by ligature for 1 or 3 h). Treatment with iron diet produced an increase in the basal levels of ferritin in all the groups. However, serum ferritin did not change after ischemia. Animals submitted to permanent ischemia had the same infarct volume in the groups studied. However, in mice submitted to transient ischemia followed by early (1 h) but not late reperfusion (3 h), iron overload increased ischemic damage and haemorrhagic transformation. Iron worsens ischemic damage induced by transient ischemia and early reperfusion. In addition, ferritin is a good indicator of body iron levels but not an acute phase protein after ischemia.
机译：铁含量高（以血清铁蛋白计）与中风后转归较差有关。但是，尚不清楚缺血性损伤是否会增加铁蛋白水平（作为急性期蛋白）或铁超负荷是否会影响中风预后。目的是研究中风对血清铁蛋白的影响以及铁超负荷对缺血性损伤的影响。瑞士小鼠接受标准饮食或补充2.5％羰基铁的饮食以产生铁超负荷。使小鼠经受永久性（通过结扎和通过原位血栓栓塞模型）或短暂性局灶性局部缺血（通过结扎1或3小时）。铁饮食治疗使所有组的铁蛋白基础水平增加。但是，缺血后血清铁蛋白没有改变。在进行研究的组中，遭受永久性缺血的动物具有相同的梗塞体积。但是，在经历短暂缺血后再进行早期（1 h）而不是后期再灌注（3 h）的小鼠中，铁超负荷增加了缺血性损伤和出血性转化。铁使短暂性缺血和早期再灌注引起的缺血性损伤加重。另外，铁蛋白是体内铁水平的良好指标，但不是缺血后的急性期蛋白。

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