• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Expression and differential response to haloperidol treatment of Cyclon/CCDC86 mRNA in schizophrenia patients
【24h】

Expression and differential response to haloperidol treatment of Cyclon/CCDC86 mRNA in schizophrenia patients

机译：氟哌啶醇对精神分裂症患者Cyclone / CCDC 86 mRNA表达的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A gene known as Cyclon (cytokine-induced protein with coiled-coil domain) or CCDC86 (coiled-coil domain-containing protein 86) is known for its expression in leukocytes in mice, where it regulates the immune response. We investigated whether Cyclon/CCDC68 is expressed in leukocytes of schizophrenia patients and whether it might be used as a biological marker for the disease endophenotype segregation. We examined the level of mRNA of Cyclon/CCDC68 in white blood cells obtained from schizophrenia patients in relapse and remission as well as in healthy controls. The mRNA of Cyclon/CCDC68 was expressed by white blood cells of both schizophrenia patients and healthy controls. There was a dichotomous change in the levels of Cyclon/CCDC68 of relapsed patients before and after treatment. High Cyclon/CCDC68 levels were associated with a recent disease and presence of psychotic symptoms, while low levels were associated with a long duration of the disease and an absence of psychotic symptoms. These data indicate that Cyclon/CCDC68 levels correlate with the clinical presentation of relapsed schizophrenia. Cyclon/CCDC68 might be involved in the immune system disturbances observed in schizophrenia.
机译：已知一种称为Cyclon（细胞因子诱导的带有卷曲螺旋结构域的蛋白）或CCDC86（包含卷曲螺旋结构域的蛋白86）的基因因其在小鼠白细胞中的表达而在其中调节免疫应答。我们调查了Cyclon / CCDC68是否在精神分裂症患者的白细胞中表达，以及它是否可用作疾病内表型分离的生物学标记。我们检查了精神分裂症患者在复发和缓解以及健康对照中获得的白细胞中Cyclon / CCDC68 mRNA的水平。精神分裂症患者和健康对照组的白细胞均表达Cyclon / CCDC68的mRNA。治疗前后复发患者的Cyclon / CCDC68水平发生了二分变化。 Cyclon / CCDC68高水平与近期疾病和精神病症状有关，而低水平与疾病持续时间长，精神病症状消失有关。这些数据表明，Cyclon / CCDC68水平与复发性精神分裂症的临床表现相关。 Cyclon / CCDC68可能与精神分裂症中观察到的免疫系统紊乱有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号