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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Ethanol modulates AMPA-induced current responses of primary somatosensory cortical neurons.
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Ethanol modulates AMPA-induced current responses of primary somatosensory cortical neurons.

机译：乙醇调节AMPA诱导的初级体感皮层神经元的电流响应。

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摘要

This study examined the effect of ethanol on responses of primary somatosensory cortical neurons to AMPA. Thin (200-250 microns) brain slices were sectioned to include the primary somatosensory cortex of rats 6-15 days after birth. Visually-identified neurons were selected for whole-cell patch clamp recording and an eight-barrel drug pipet assembly was used to deliver test agents. Ethanol (5-100 mM) either positively or negatively modulated AMPA (100 microM)-induced current to varying degrees in approximately 70% of primary somatosensory cortical neurons. As revealed in layer V large pyramidal neurons, the outcome of an ethanol-induced modulation appeared to be age-dependent, the trend being one of potentiation in slices derived from younger rats (postnatal days 6-9) but one of attenuation in those derived from older animals (postnatal days 13-15). These findings indicate that ethanol at physiologically relevant concentrations modulates non-NMDA receptor-mediated responses of neurons in the rat primary somatosensory cortex.
机译：这项研究检查了乙醇对原代体感皮层神经元对AMPA反应的影响。将薄的（200-250微米）脑切片切成薄片，包括出生后6-15天的大鼠原代体感皮层。选择视觉识别的神经元进行全细胞膜片钳记录，并使用八桶吸管组件输送测试剂。在大约70％的初级体感皮层神经元中，乙醇（5-100 mM）对AMPA（100 microM）产生的电流产生正向或负向调制。正如在第V层大型锥体神经元中所揭示的那样，乙醇诱导的调节作用的结果似乎与年龄有关，这种趋势是年轻大鼠（出生后6至9天）切片中的增强作用之一，而在衍生后的切片中则是衰减作用之一。来自大龄动物（产后13-15天）。这些发现表明，生理上相关浓度的乙醇可调节大鼠原代体感皮层中非NMDA受体介导的神经元反应。

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