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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Dynamic downregulation of Nogo receptor expression in the rat forebrain by amphetamine
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Dynamic downregulation of Nogo receptor expression in the rat forebrain by amphetamine

机译：苯丙胺动态下调大鼠前脑Nogo受体表达

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摘要

Nogo receptors (NgRs) are a family of cell surface receptors that are broadly expressed in the mammalian brain. These receptors could serve as an inhibitory element in the regulation of activity-dependent axonal growth and spine and synaptic formation in the adult animal brain. Thus, through balancing the structural response to changing cellular and synaptic inputs, NgRs participate in constructing activitydependent morphological plasticity. Psychostimulants have been well documented to induce morphological plasticity critical for addictive properties of stimulants, although underlying molecular mechanisms are poorly understood. In this study, we initiated a study to investigate the response of NgRs to a stimulant. We tested the effect of acute administration of amphetamine on protein expression of two principal NgR subtypes (NgR1 and NgR2) in the rat striatum, medial prefrontal cortex (mPFC) and hippocampus. We found that a single injection of amphetamine induced a rapid and time-dependent decrease in NgR1 and NgR2 expression in the striatum and mPFC. A relatively delayed and time-dependent decrease in expression of the two receptors was seen in the hippocampus. The drug-induced decrease in NgR1 and NgR2 expression in the three forebrain regions was dose-dependent. A behaviorally active dose of the drug was required to trigger a significant reduction in NgR1 and NgR2 expression. These data indicate that NgRs are subject to the regulation by the stimulant. Amphetamine exposure exerts the inhibitory modulation of basal NgR1 and NgR2 expression in the key structures of reward circuits in vivo.
机译：Nogo受体（NgRs）是在哺乳动物脑中广泛表达的细胞表面受体家族。这些受体可以在成年动物脑中调节依赖于活性的轴突生长以及脊柱和突触的形成中。因此，通过平衡对变化的细胞和突触输入的结构响应，NgR参与构建依赖活性的形态可塑性。尽管对潜在的分子机制了解甚少，但精神兴奋剂已被充分证明可诱导对兴奋剂上瘾的性质至关重要的形态可塑性。在这项研究中，我们启动了一项研究，以研究NgR对兴奋剂的反应。我们测试了苯丙胺对大鼠纹状体，内侧前额叶皮层（mPFC）和海马体中两种主要NgR亚型（NgR1和NgR2）蛋白质表达的影响。我们发现，单次注射苯丙胺会引起纹状体和mPFC中NgR1和NgR2表达的快速且时间依赖性降低。在海马体中观察到两种受体表达的相对延迟和时间依赖性降低。药物诱导的三个前脑区域中NgR1和NgR2表达的下降是剂量依赖性的。需要有行为活性剂量的药物才能触发NgR1和NgR2表达的显着降低。这些数据表明，NgR受兴奋剂的调节。苯丙胺暴露在体内奖励回路的关键结构中对基础NgR1和NgR2表达产生抑制性调节。

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