The functions of UCH-L1 and its relation to neurodegenerative diseases.

Setsuie R; Wada K

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The functions of UCH-L1 and its relation to neurodegenerative diseases.

机译：UCH-L1的功能及其与神经退行性疾病的关系。

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Parkinson's disease (PD) and Alzheimer's disease (AD), the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is involved in the pathogenesis of both of these neurodegenerative diseases. Several functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on recent findings on the functions and the regulation of UCH-L1, in particular those that relate to PD and AD.

机译：帕金森氏病（PD）和阿尔茨海默氏病（AD）是最常见的神经退行性疾病，由遗传和环境因素共同引起。泛素羧基末端水解酶L1（UCH-L1）是一种去泛素化酶，参与这两种神经退行性疾病的发病机理。除了泛素水解酶之外，还提出了UCH-L1的几种功能。这些包括充当泛素连接酶和稳定单泛素。这篇综述着重于关于UCH-L1的功能和调节的最新发现，尤其是与PD和AD相关的发现。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2007年第4期|共7页
作者
Setsuie R; Wada K;
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正文语种 eng
中图分类生物化学;
关键词
UCH-L1; Ubiquitin; PUPILLARY DISTANCE; Admitting diagnosis; Hydrolases; 遍在蛋白质; 水解酶类;

机译：UCH-L1;Ubiquitin;PUPILLARY DISTANCE;Admitting diagnosis;Hydrolases;遍在蛋白质;水解酶类;

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1. The functions of UCH-L1 and its relation to neurodegenerative diseases. [J] . Setsuie R, Wada K Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2007,第2a4期

机译：UCH-L1的功能及其与神经退行性疾病的关系。
2. Multiple functions of PINK1 at different intracellular locations: beyond neurodegenerative diseases. [J] . Murata H, Sakaguchi M, Kataoka K, Cell cycle . 2011,第10期

机译：不同的细胞内位置的粉红色1的多种功能：除神经变性疾病之外。
3. Multiple functions of PINK1 at different intracellular locations: beyond neurodegenerative diseases. [J] . Murata H, Sakaguchi M, Kataoka K, Cell cycle . 2011,第10期

机译：PINK1在不同的细胞内位置的多种功能：超越神经变性疾病。
4. Investigations on the Functional connectivity disruptive patterns of progressive neurodegenerative disorders [C] . Kavitha A., Sucharitha S. Prakash, Sreeja P., Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：进行性神经退行性疾病的功能连接破坏模式的研究
5. Molecular function of parkin in neurodegenerative diseases. [D] . Tsai, Yien Che. 2003

机译：帕金蛋白在神经退行性疾病中的分子功能。
6. Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure distribution and roles in brain function and dysfunction [O] . Paul Bishop, Dan Rocca, Jeremy M. Henley -1

机译：泛素C末端水解酶L1（UCH-L1）：结构分布及其在脑功能和功能障碍中的作用
7. Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. [O] . Stolp, HB, Dziegielewska, KM 2009

机译：综述：发育性炎症和血脑屏障功能障碍在神经发育和神经退行性疾病中的作用。

The functions of UCH-L1 and its relation to neurodegenerative diseases.

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