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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Imbalance in oxidant/antioxidant system in different brain regions of rat after the infection of Japanese encephalitis virus.
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Imbalance in oxidant/antioxidant system in different brain regions of rat after the infection of Japanese encephalitis virus.

机译：日本脑炎病毒感染后大鼠不同脑区的氧化/抗氧化系统失衡。

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摘要

The imbalance in redox equilibrium is associated with several viral diseases however its role in Japanese encephalitis (JE) has not been reported. In the present study, we report the status of oxidant/antioxidant system in different brain regions in rat model of JE. Twelve days old Wistar strain rats were inoculated intracerebrally with a dose of 3x10(6)pfu of JE virus (JEV). The activity of manganese superoxide dismutase (Mn-SOD), catalase (CAT), glutathione peroxidase (GPx) and the levels of reduced glutathione (GSH) and malonaldialdehyde (MDA) were estimated in corpus striatum, frontal cortex, thalamus and midbrain on 0, 10 and 20 days post-inoculation (dpi). A significant increase in MDA levels in striatum (p<0.01), cortex (p<0.01), thalamus (p<0.01) and midbrain (p<0.01) was observed in JEV infected rats on 10 and 20dpi compared to controls. The activity of CAT, GPx and the levels of GSH were significantly decreased in all the brain regions studied on 10 and 20dpi compared to controls. However, the activity of Mn-SOD in striatum (p<0.01), cortex (p<0.05), thalamus (p<0.01) and midbrain (p<0.01) were significantly increased on 10 and 20dpi in JEV infected rats compared to controls. The activity of Mn-SOD and MDA levels were significantly increased whereas the activity of CAT, GPx and GSH levels were significantly decreased in all the brain regions studied as the disease progressed from 0 to 20dpi. The maximum alteration in oxidant/antioxidant balance was observed in thalamus and midbrain. The results of the present study demonstrate that antioxidant defense mechanism is impaired after the infection of JE virus suggesting its critical role in cellular injury in brain regions. The findings could be beneficial to understand the role of oxidative stress in the pathogenesis of JE and therapeutic interventions.
机译：氧化还原平衡的失衡与几种病毒性疾病有关，但尚未报道其在日本脑炎（JE）中的作用。在本研究中，我们报告了JE大鼠模型中不同大脑区域的氧化剂/抗氧化剂系统的状态。给12天大的Wistar品系大鼠脑内接种3x10（6）pfu JE病毒（JEV）。估计0体纹状体，额叶皮层，丘脑和中脑中的锰超氧化物歧化酶（Mn-SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx）的活性以及还原型谷胱甘肽（GSH）和丙二醛（MDA）的水平，接种后10天和20天（dpi）。与对照组相比，在10和20 dpi感染JEV的大鼠中，纹状体（p <0.01），皮质（p <0.01），丘脑（p <0.01）和中脑（p <0.01）的MDA水平显着增加。与对照组相比，在10dpi和20dpi下研究的所有大脑区域中CAT，GPx的活性和GSH的水平均显着降低。然而，与对照组相比，JEV感染大鼠在10和20dpi时纹状体（p <0.01），皮质（p <0.05），丘脑（p <0.01）和中脑（p <0.01）的Mn-SOD活性显着增加。 。随着疾病的发展，从0到20dpi，Mn-SOD和MDA的活性显着增加，而CAT，GPx和GSH的活性显着下降。在丘脑和中脑中观察到氧化剂/抗氧化剂平衡的最大改变。本研究的结果表明，JE病毒感染后抗氧化防御机制受损，表明其在脑区域细胞损伤中起关键作用。该发现可能有助于了解氧化应激在脑脊髓炎的发病机理和治疗干预中的作用。

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