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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Effect of nitroxyl on the hamster retinal nitridergic pathway.
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Effect of nitroxyl on the hamster retinal nitridergic pathway.

机译：硝氧基对仓鼠视网膜硝化途径的影响。

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摘要

There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO(-)), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to comparatively analyze the effect of HNO and NO on the retinal nitridergic pathway in the golden hamster. For this purpose, sodium trioxodinitrate (Angeli's salt) and diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO) were used as HNO and NO releasers, respectively. Angeli's salt and DEA/NO significantly decreased nitric oxide synthase activity. In addition, Angeli's salt (but not DEA/NO) significantly decreased l-arginine uptake. DEA/NO significantly increased cGMP accumulation at low micromolar concentrations, while Angeli's salt affected this parameter with a threshold concentration of 200muM. Although Angeli's salt and DEA/NO significantly diminished reduced glutathione and protein thiol levels in a similar way, DEA/NO was significantly more effective than AS in increasing S-nitrosothiol levels. None of these compounds increased retinal lipid peroxidation. These results suggest that HNO could regulate the hamster retinal nitridergic pathway by acting through a mechanism that only partly overlaps with that involved in NO response.
机译：关于一氧化氮（NO）在视网膜生理中的作用的证据越来越多。近来，人们对NO的另一种氧化还原形式的功能作用产生了兴趣，即硝氧基（HNO / NO（-）），因为它是由许多不同的生化反应形成的。本报告的目的是比较分析HNO和NO对金仓鼠视网膜氮化途径的影响。为此，分别使用三氧合己二酸钠（安格利盐）和二乙基铵（Z）-1-（N，N-二乙基氨基）重氮-1-1,2-二醇盐（DEA / NO）作为NO释放剂。 。安吉利盐和DEA / NO明显降低一氧化氮合酶活性。此外，安吉利盐（但不是DEA / NO）显着降低了L-精氨酸的摄取。在低微摩尔浓度下，DEA / NO显着增加了cGMP的积累，而安吉利的盐以200μM的阈值浓度影响了该参数。尽管安吉利的盐和DEA / NO以类似的方式显着降低了降低的谷胱甘肽和蛋白质硫醇水平，但DEA / NO在提高S-亚硝基硫醇水平上比AS更为有效。这些化合物均未增加视网膜脂质过氧化作用。这些结果表明，HNO可以通过仅与参与NO反应的机制部分重叠的机制起作用，从而调节仓鼠视网膜的硝化途径。

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