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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease
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Upregulation of AMPA receptor GluR2 (GluA2) subunits in subcortical ischemic vascular dementia is repressed in the presence of Alzheimer's disease

机译：在阿尔茨海默氏病的存在下，抑制皮质下缺血性血管性痴呆中AMPA受体GluR2（GluA2）亚基的上调

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摘要

Glutamatergic AMPA receptors are of clinical significance in dementia because of their roles in mediating fast excitatory neurotransmission and other synaptic events relevant to cognition. Reductions in the AMPA receptor GluR2 subunit are well-established in Alzheimer's disease (AD), but the status of GluR2 in subcortical ischemic vascular dementia (SIVD) and mixed AD/S1VD (MIX) has not been investigated. In this study we measured GluR2 immunoreactivity and mRNA levels in the postmortem neocortex of a longitudinally assessed cohort of SIVD and MIX, together with age-matched controls. We found that GluR2 immunoreactivity and mRNA were up-regulated in SIVD, but remained unchanged in MIX. Furthermore, higher GluR2 immunoreactivity was associated with milder cognitive impairment and lower concentrations of A(342 peptide and phosphorylated tau. Our study suggests that GluR2 upregulation may be an adaptive process in SIVD, and that this process is repressed in the presence of concomitant AD in mixed dementia.
机译：谷氨酸能AMPA受体在痴呆症中具有临床意义，因为它们在介导快速兴奋性神经传递和其他与认知有关的突触事件中发挥作用。在阿尔茨海默氏病（AD）中，AMPA受体GluR2亚基的减少是公认的，但是尚未研究GluR2在皮层下缺血性血管性痴呆（SIVD）和混合型AD / S1VD（MIX）中的状态。在这项研究中，我们测量了SIVD和MIX的纵向评估队列以及年龄匹配的对照的死后新皮层中的GluR2免疫反应性和mRNA水平。我们发现SIVD中GluR2免疫反应性和mRNA上调，但在MIX中保持不变。此外，较高的GluR2免疫反应性与较轻的认知障碍和较低的A（342肽和磷酸化tau浓度有关。我们的研究表明，GluR2上调可能是SIVD的一个适应性过程，并且在伴有AD的情况下该过程受到抑制。混合性痴呆。

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