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首页> 外文期刊>Neurobiology of learning and memory >Propranolol reduces emotional distraction in working memory: a partial mediating role of propranolol-induced cortisol increases?
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Propranolol reduces emotional distraction in working memory: a partial mediating role of propranolol-induced cortisol increases?

机译：普萘洛尔减少工作记忆中的情绪分散：普萘洛尔诱导的皮质醇的部分介导作用增加了吗？

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摘要

Noradrenalin modulates prefrontal function, such as working memory (WM), and is associated with enhanced distractibility, and enhanced memory for emotional events and stimuli. The beta-blocker propranolol has been shown to reduce memory for emotional stimuli. Herein we describe investigations aimed at assessing whether the administration of propranolol would reduce the interference by emotional distractions during WM performance. In a between-subjects design, 48 young, healthy men received 80 mg propranolol (n=25) or placebo (n=23), before performing an "emotional Sternberg task" with neutral and negatively arousing distracters. Compared to placebo, propranolol impaired WM at low load, however, it also reduced the interference by emotional distracters at high load. Furthermore, an explorative moderated-mediation analysis indicated that the observed propranolol effects on emotional distraction were partially mediated by cortisol. In future non-clinical and clinical memory studies using propranolol administration, cortisol elevations should be monitored to further investigate the potential mediating role of cortisol.
机译：去甲肾上腺素调节前额叶功能，例如工作记忆（WM），并与增强的注意力分散性和增强的情绪事件和刺激记忆有关。 β-阻断剂普萘洛尔已显示减少情绪刺激的记忆。本文中，我们描述了旨在评估心得安在WM表现期间是否能减少情绪分心的干扰的研究。在受试者之间的设计中，有48名年轻健康的男性接受了80 mg普萘洛尔（n = 25）或安慰剂（n = 23），然后用中性和消极的干扰物执行“情绪性Sternberg任务”。与安慰剂相比，普萘洛尔在低负荷时会损害WM，但是，它也减少了高负荷时情绪干扰者的干扰。此外，探索性中度调解分析表明，观察到的心得安对情绪分散的作用部分由皮质醇介导。在未来使用普萘洛尔给药的非临床和临床记忆研究中，应监测皮质醇升高，以进一步研究皮质醇的潜在介导作用。

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