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首页> 外文期刊>Neurogastroenterology and motility >Relationship between symptom pattern, assessed by the PAGI-SYM 1 questionnaire, and gastric sensorimotor dysfunction in functional dyspepsia
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Relationship between symptom pattern, assessed by the PAGI-SYM 1 questionnaire, and gastric sensorimotor dysfunction in functional dyspepsia

机译：通过PAGI-SYM 1问卷评估的症状模式与功能性消化不良的胃感觉运动功能障碍之间的关系

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The patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM) questionnaire was recently developed and validated for the evaluation of therapeutic responsiveness in functional dyspepsia (FD). Functional dyspepsia is a heterogeneous disorder, with different pathophysiological mechanisms underlying the symptom pattern. The relationship between PAGI-SYM scores and putative pathophysiological mechanisms has not been studied. The aim of this study was to evaluate the relationship between PAGI-SYM subscales and gastric emptying, gastric sensitivity and gastric accommodation in FD. A total of 161 consecutive FD patients underwent Helicobacter pylori (HP), gastric barostat and standardized gastric emptying testing (n = 126), and completed the PAGI-SYM questionnaire. Relationships between scores for the six subscales (heartburn/regurgitation, nausea/vomiting, fullness/satiety, bloating, upper abdominal pain, lower abdominal pain) and gastric function were analysed using Pearson's linear correlation, multiple regression analysis, chi-square and Student's t-tests. Gastric emptying was significantly correlated with scores for heartburn/regurgitation (r = 0.26), nausea/vomiting (r = 0.19), fullness/satiety (r = 0.20), bloating (r = 0.21) and lower abdominal pain (r = 0.22; all P < 0.05). Patients with delayed emptying had significantly higher scores for each of these subscales (all P < 0.05). Discomfort volume during gastric distension was significantly correlated with scores for fullness/satiety (r = -0.27), bloating (r = -0.23), heartburn/regurgitation (r = -0.21), and upper abdominal pain (r = -0.20). Patients with hypersensitivity to distension had significantly higher scores for fullness/satiety (P < 0.05). At different cut-off levels of symptom severities, consistent associations were found between fullness/satiety and gastric discomfort volume, between preprandial volumes and upper abdominal pain, compliance and upper abdominal pain, and between bloating and gastric discomfort volume. Multiple regression analysis revealed that gastric emptying rate contributed significantly to models for the severity of these subscales. The importance of discomfort volume disappeared in favour of gender when sex was included in the model. No significant correlations were found with HP status or with gastric accommodation. PAGI-SYM scores are mainly correlated with gastric emptying rate and with gastric hypersensitivity. Multivariate analysis suggests that the questionnaire may be useful in the evaluation of gastroprokinetics. Its role in the evaluation of drugs that alter gastric sensitivity is less clear.
机译：最近开发了上消化道症状严重程度指数（PAGI-SYM）问卷的患者评估，并已通过评估用于功能性消化不良（FD）的治疗反应性评估。功能性消化不良是一种异质性疾病，其症状模式具有不同的病理生理机制。尚未研究PAGI-SYM评分与假定的病理生理机制之间的关系。这项研究的目的是评估FD中PAGI-SYM量表与胃排空，胃敏感性和胃适应性之间的关系。总共161名连续的FD患者接受了幽门螺杆菌（HP），胃恒压器和标准化胃排空测试（n = 126），并完成了PAGI-SYM问卷。使用皮尔森线性相关，多元回归分析，卡方和学生t值分析了六个分量表（胃灼热/反流，恶心/呕吐，饱腹/饱腹感，腹胀，上腹痛，下腹痛）的得分与胃功能之间的关系。 -测试。胃排空与胃灼热/反流（r = 0.26），恶心/呕吐（r = 0.19），饱腹/饱腹（r = 0.20），腹胀（r = 0.21）和下腹痛（r = 0.22;所有P <0.05）。排空延迟的患者在每个这些量表中的得分均显着更高（所有P <0.05）。胃胀气期间的不适量与饱胀/饱满（r = -0.27），腹胀（r = -0.23），胃灼热/反流（r = -0.21）和上腹痛（r = -0.20）的得分显着相关。对扩张过敏的患者的饱腹感/饱足感得分显着更高（P <0.05）。在不同的症状严重程度截断水平下，饱腹感和饱足感与胃部不适感，餐前压痛与上腹部痛，顺应性与上腹痛以及腹胀与胃部不适感之间存在一致的关联。多元回归分析显示，胃排空率对这些分量表的严重性模型有显着影响。当在模型中包括性别时，不适感的重要性不再对性别有利。没有发现与HP状态或胃适应性有显着相关性。 PAGI-SYM评分主要与胃排空率和胃过敏有关。多变量分析表明，该调查表可能对胃动力的评估有用。它在改变胃敏感性药物评估中的作用尚不清楚。

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