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首页> 外文期刊>Neuron >TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
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TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.

机译：TARP亚型差异性和剂量依赖性地控制突触AMPA受体门控。

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A family of transmembrane AMPA receptor regulatory proteins (TARPs) profoundly affects the trafficking and gating of AMPA receptors (AMPARs). Although TARP subtypes are differentially expressed throughout the CNS, it is unclear whether this imparts functional diversity to AMPARs in distinct neuronal populations. Here, we examine the effects of each TARP subtype on the kinetics of AMPAR gating in heterologous cells and in neurons. We report a striking heterogeneity in the effects of TARP subtypes on AMPAR deactivation and desensitization, which we demonstrate controls the time course of synaptic transmission. In addition, we find that some TARP subtypes dramatically slow AMPAR activation kinetics. Synaptic AMPAR kinetics also depend on TARP expression level, suggesting a variable TARP/AMPAR stoichiometry. Analysis of quantal synaptic transmission in a TARP gamma-4 knockout (KO) mouse corroborates our expression data and demonstrates that TARP subtype-specific gating of AMPARs contributes to the kineticsof native AMPARs at central synapses.
机译：跨膜AMPA受体调节蛋白（TARP）家族深刻影响AMPA受体（AMPAR）的转运和门控。尽管TARP亚型在整个CNS中差异表达，但尚不清楚这是否赋予不同神经元群体AMPARs功能多样性。在这里，我们检查了异种细胞和神经元中每个TARP亚型对AMPAR门控动力学的影响。我们报告了惊人的异质性对AMPAR失活和脱敏的TARP亚型的影响，我们证明了控制突触传递的时间过程。此外，我们发现某些TARP亚型会大大减慢AMPAR活化动力学。突触AMPAR动力学还取决于TARP表达水平，表明TARP / AMPAR化学计量是可变的。在TARP gamma-4基因敲除（KO）小鼠中定量突触传递的分析证实了我们的表达数据，并证明了AMPAR的TARP亚型特异性门控有助于中枢突触中天然AMPAR的动力学。

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