...
首页> 外文期刊>Neuron >Central brain neurons expressing doublesex regulate female receptivity in Drosophila
【24h】

Central brain neurons expressing doublesex regulate female receptivity in Drosophila

机译:表达双性恋的中枢神经元调节果蝇中的女性接受能力。

获取原文
获取原文并翻译 | 示例
           

摘要

Drosophila melanogaster females respond to male courtship by either rejecting the male or allowing copulation. The neural mechanisms underlying these female behaviors likely involve the integration of sensory information in the brain. Because doublesex (dsx) controls other aspects of female differentiation, we asked whether dsx-expressing neurons mediate virgin female receptivity to courting males. Using intersectional techniques to manipulate the activities of defined subsets of dsx-expressing neurons, we found that activation of neurons in either the pCd or pC1 clusters promotes receptivity, while silencing these neurons makes females unreceptive. Furthermore, pCd and pC1 neurons physiologically respond to the male-specific pheromone cis-vaccenyl acetate (cVA), while pC1 neurons also respond to male courtship song. The pCd and pC1 neurons expressing dsx in females do not express transcripts from the fruitless (fru) P1 promoter. Thus, virgin female receptivity is controlled at least in part by neurons that are distinct from those governing male courtship.
机译:果蝇的雌性通过拒绝雄性或允许交配来回应雄性求爱。这些女性行为的潜在神经机制可能涉及大脑中感觉信息的整合。由于doublesex(dsx)控制着女性分化的其他方面,因此我们询问表达dsx的神经元是否介导处女女性对求爱男性的接受能力。使用交叉技术来操纵表达dsx的神经元的定义子集的活动,我们发现pCd或pC1簇中神经元的激活会促进接受性,而沉默这些神经元会使雌性无法接受。此外,pCd和pC1神经元在生理上对雄性特异信息素顺式-乙酸乙烯酯(cVA)做出反应,而pC1神经元也对雄性求爱曲作出反应。在雌性中表达dsx的pCd和pC1神经元不表达无果(果)P1启动子的转录本。因此,原始女性的接受度至少部分地由与控制男性求爱的神经元不同的神经元控制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号