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首页> 外文期刊>Neuron >Minigenes impart odorant receptor-specific axon guidance in the olfactory bulb.
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Minigenes impart odorant receptor-specific axon guidance in the olfactory bulb.

机译：小基因在嗅球中赋予气味受体特异性轴突指导。

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摘要

An olfactory sensory neuron (OSN) expresses selectively one member from a repertoire of approximately 1000 odorant receptor (OR) genes and projects its axon to a specific glomerulus in the olfactory bulb. Both processes are here recapitulated by MOR23 and M71 OR minigenes, introduced into mice. Minigenes of 9 kb and as short as 2.2 kb are selectively expressed by neurons that do not coexpress the endogenous gene but coproject their axons to the same glomeruli. Deletion of a 395 bp upstream region in the MOR23 minigene abolishes expression. In this region we recognize sequence motifs conserved in many OR genes. Transgenic lines expressing the OR in ectopic epithelial zones form ectopic glomeruli, which also receive input from OSNs expressing the cognate endogenous receptor. This suggests a recruitment through homotypic interactions between OSNs expressing the same OR.
机译：嗅觉感觉神经元（OSN）从大约1000个嗅觉受体（OR）基因库中选择性表达一个成员，并将其轴突投射到嗅球中的特定肾小球上。这两个过程在这里都被引入小鼠的MOR23和M71 OR小基因概括。 9 kb短至2.2 kb的小基因由神经元选择性表达，这些神经元不共表达内源基因，而是将其轴突共投射到同一肾小球上。 MOR23小基因中395 bp上游区域的删除废除了表达。在该区域中，我们识别出许多OR基因中保守的序列基序。在异位上皮区表达OR的转基因品系形成异位肾小球，它也从表达同源内源性受体的OSN接收输入。这表明通过表达相同OR的OSN之间的同型相互作用进行募集。

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