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首页> 外文期刊>Neuron >Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning
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Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning

机译：社会剥夺增强了VTA的突触可塑性和药物诱导的情境学习

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Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social life, particularly during adolescence, increase addiction vulnerability. Social isolation in rodents has been used extensively to model the effects of deficient social experience, yet its impact on learning and memory processes underlying addiction remains elusive. Here, we show that social isolation of rats during a critical period of adolescence (postnatal days 21-42) enhances long-term potentiation of NMDA receptor (NMDAR)-mediated glutamatergic transmission in the ventral tegmental area (VTA). This enhancement, which is caused by an increase in metabotropic glutamate receptor-dependent Ca2+ signaling, cannot be reversed by subsequent resocialization. Notably, memories of amphetamine- and ethanol-paired contextual stimuli are acquired faster and, once acquired, amphetamine-associated contextual memory is more resistant to extinction in socially isolated rats. We propose that NMDAR plasticity in the VTA may represent a neural substrate by which early life deficits in social experience increase addiction vulnerability. Deficits in social life, particularly during adolescence, increase addiction vulnerability. Whitaker et al. show that social isolation of rats during a critical period of adolescence enhances synaptic plasticity in the brain reward circuit, thereby facilitating the formation of drug-related memories.
机译：吸毒成瘾的部分原因是与毒品有关的强大记忆。社会生活的不足，尤其是在青春期，会增加成瘾的脆弱性。啮齿动物中的社会隔离已被广泛用来模拟缺乏社会经验的影响，但其对成瘾基础的学习和记忆过程的影响仍然难以捉摸。在这里，我们表明，在青春期的关键时期（出生后的第21-42天），大鼠的社会隔离增强了NMDA受体（NMDAR）介导的腹侧被盖区（VTA）的谷氨酸能传递的长期增强。这种增强是由代谢型谷氨酸受体依赖性Ca2 +信号转导的增加引起的，不能通过随后的重新社会化来逆转。值得注意的是，苯丙胺和乙醇配对的情境刺激的记忆获得更快，一旦获得，与苯丙胺相关的情境记忆在社会隔离的大鼠中更容易灭绝。我们提出，VTA中的NMDAR可塑性可能代表了神经底物，社交经验中的早期生活不足会增加成瘾的易感性。社会生活的不足，尤其是在青春期，会增加成瘾的脆弱性。 Whitaker等。研究表明，在青春期的关键时期大鼠的社会隔离增强了大脑奖励回路中的突触可塑性，从而促进了与药物相关的记忆的形成。

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