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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Chordoid meningiomas: Incidence and clinicopathological features of a case series over 18 years
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Chordoid meningiomas: Incidence and clinicopathological features of a case series over 18 years

机译：脉络膜脑膜瘤：18年以上病例系列的发病率和临床病理特征

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摘要

Chordoid meningioma (CM) is a rare subtype of meningioma, classified as grade II, which exhibits a high rate of recurrence following subtotal resection. We retrospectively examined nine cases of chordoid meningioma over a case series of 1743 meningiomas (0.52%) operated upon at our institution from 1995 to 2013. All the reported clinicopathological findings were analyzed. Two hundred and twenty-one CM cases have been published to date worldwide and few single-center large case series have been issued. Seventy-five percent of the cases that underwent subtotal resection at our institution had recurrence within 1 year. Total resection of the tumor should be the major objective of surgery to reduce the possibility of tumor recurrence. The percentage of chordoid features within the tumor specimen could assist in predicting the pathogenesis of the lesion. The correlation of the index of proliferation to recurrence rate is still controversial. Much debate exists with regard to the role of adjuvant radiotherapy in CM cases. Immunohistochemical, cytological and ultrastructural studies should be used in combination to assure a correct diagnosis of CM. Owing to the rare occurrence of this meningioma subtype, larger case series are required to assist in providing a reference for diagnosis and to improve the therapeutic management of CM.
机译：脉络膜脑膜瘤（CM）是一种罕见的脑膜瘤亚型，分类为II级，在全切除后表现出较高的复发率。我们回顾性研究了1995年至2013年在我们机构进行的1743例脑膜瘤病例（0.52％）中的9例脉络膜脑膜瘤病例。所有报告的临床病理结果均经过分析。迄今为止，全球已经发布了212个CM案例，并且很少发布单中心大案例系列。在我们机构中进行大宗切除的病例中有百分之七十五在一年内复发。肿瘤的全切除应该是减少肿瘤复发可能性的主要手术目标。肿瘤标本中脉络膜特征的百分比可以帮助预测病变的发病机理。增殖指数与复发率之间的相关性仍存在争议。关于辅助放疗在CM病例中的作用存在许多争议。免疫组织化学，细胞学和超微结构研究应结合使用，以确保正确诊断CM。由于这种脑膜瘤亚型的罕见发生，需要更大的病例系列来帮助提供诊断参考和改善CM的治疗管理。

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