• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Regulatory Logic of Pan-Neuronal Gene Expression in C-elegans
【24h】

Regulatory Logic of Pan-Neuronal Gene Expression in C-elegans

机译：C-线虫泛神经基因表达的调控逻辑。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While neuronal cell types display an astounding degree of phenotypic diversity, most if not all neuron types share a core panel of terminal features. However, little is known about how pan-neuronal expression patterns are genetically programmed. Through an extensive analysis of the cis-regulatory control regions of a battery of pan-neuronal C. elegans genes, including genes involved in synaptic vesicle biology and neuropeptide signaling, we define a common organizational principle in the regulation of pan-neuronal genes in the form of a surprisingly complex array of seemingly redundant, parallel-acting cis-regulatory modules that direct expression to broad, overlapping domains throughout the nervous system. These parallel-acting cis-regulatory modules are responsive to a multitude of distinct trans-acting factors. Neuronal gene expression programs therefore fall into two fundamentally distinct classes. Neuron-type-specific genes are generally controlled by discrete and non-redundantly acting regulatory inputs, while pan-neuronal gene expression is controlled by diverse, coincident and seemingly redundant regulatory inputs.
机译：虽然神经元细胞类型表现出惊人的表型多样性，但大多数（如果不是全部）神经元类型共享终端特征的核心面板。但是，关于泛神经元表达模式如何遗传编程知之甚少。通过广泛分析一系列泛神经线虫基因（包括与突触囊泡生物学和神经肽信号传导有关的基因）的顺式调控区域，我们定义了调控泛神经元基因的共同组织原理。形式的惊人复杂的看似冗余的，平行作用的顺式调控模块，可将表达引导至整个神经系统的广泛重叠域。这些平行作用的顺式调节模块对多种不同的反式作用因子作出响应。因此，神经元基因表达程序分为两个基本不同的类别。神经元类型特异性基因通常由离散的和非冗余作用的调控输入控制，而泛神经元基因的表达则受多种，一致且看似冗余的调控输入控制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号