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首页> 外文期刊>Neuron >Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.
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Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.

机译:基底外侧杏仁核神经元通过刺激伏伏核神经元促进寻求奖励的行为。

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摘要

Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established. Here, we test the hypothesis that the BLA drives NAc neuronal responses to reward-predictive cues. First, using a disconnection experiment, we show that the BLA and dopamine projections to the NAc interact to promote the reward-seeking behavioral response. Next, we demonstrate that BLA neuronal responses to cues precede those of NAc neurons and that cue-evoked excitation of NAc neurons depends on BLA input. These results indicate that BLA input is required for dopamine to enhance the cue-evoked firing of NAc neurons and that this enhanced firing promotes reward-seeking behavior.
机译:伏伏核(NAc)和基底外侧杏仁核(BLA)均有助于学习行为选择。两种编码奖励预测线索的结构中的神经元可能是对此类线索做出响应的决定的基础,但尚未建立BLA通过其影响奖励寻求行为的神经回路。在这里,我们测试了BLA推动NAc神经元对奖励预测线索的反应的假设。首先,使用断开连接实验,我们证明了BLA和多巴胺对NAc的预测相互作用以促进寻求奖励的行为反应。接下来,我们证明BLA神经元对线索的反应先于NAc神经元的线索,并且NAc神经元的线索诱发的兴奋取决于BLA输入。这些结果表明,多巴胺需要BLA输入,以增强NAc神经元的提示诱发的放电,并且这种增强的放电可促进寻求奖励的行为。

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