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首页> 外文期刊>Neurochemical research >The Effects of Amiloride on Seizure Activity, Cognitive Deficits and Seizure-Induced Neurogenesis in a Novel Rat Model of Febrile Seizures
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The Effects of Amiloride on Seizure Activity, Cognitive Deficits and Seizure-Induced Neurogenesis in a Novel Rat Model of Febrile Seizures

机译：阿米洛利对高热惊厥新型大鼠模型癫痫发作活动，认知缺陷和癫痫发作诱导的神经发生的影响。

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Accumulating data suggest that sodium-hydrogen exchangers (NHEs) play a key role in modulating seizure activity by regulating neuronal pH in the brain. Amiloride, an inhibitor of NHEs, has been demonstrated to be effective in many seizure models, although its efficacy for prolonged febrile seizures (FS) remains unclear. In this study, we investigated whether amiloride could produce neuroprotective effects in a prolonged FS model in which FS were induced in rat pups at postnatal day 10 using a heated air approach. Amiloride was administered by intraperitoneal injection at three different doses (0.65, 1.3 and 2.6 mg/kg). Pretreatment with amiloride significantly delayed the onset of the first episode of limbic seizures, whereas posttreatment with amiloride decreased escape latency in the Morris water maze test compared to post-FS treatment with saline. Amiloride also inhibited seizure-induced aberrant neurogenesis. In conclusion, this study demonstrated the antiseizure activity of amiloride. In particular, posttreatment with amiloride resulted in cognitive improvement; this finding provides crucial evidence of the neuroprotective function of amiloride and of the therapeutic potential of amiloride in FS.
机译：越来越多的数据表明，钠氢交换剂（NHE）通过调节大脑中的神经元pH在调节癫痫发作活动中起关键作用。尽管尚不清楚氨氯雷德（NHEs的抑制剂）在许多癫痫发作模型中均有效，但其对长时间高热惊厥（FS）的疗效尚不清楚。在这项研究中，我们调查了阿米洛利在延长的FS模型中是否可以产生神经保护作用，该模型在出生后第10天使用加热空气的方法在大鼠幼鼠中诱发FS。阿米洛利以三种不同剂量（0.65、1.3和2.6 mg / kg）通过腹膜内注射给药。阿米洛利的预处理显着延迟了边缘发作的首发发作，而与莫里斯水迷宫测试相比，阿米洛利的后处理在莫里斯水迷宫测试中减少了逃逸潜伏期。阿米洛利还抑制癫痫发作诱导的异常神经发生。总之，这项研究证明了阿米洛利的抗癫痫活性。特别是，用阿米洛利进行后处理可改善认知能力;这一发现提供了阿米洛利的神经保护功能以及阿米洛利在FS中的治疗潜力的重要证据。

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