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首页> 外文期刊>Neuron >New Modules Are Added to Vibrissal Premotor Circuitry with the Emergence of Exploratory Whisking
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New Modules Are Added to Vibrissal Premotor Circuitry with the Emergence of Exploratory Whisking

机译：随着探索性搅拌的出现，新的模块被添加到振动前电动电路中

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Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae (" whisking" ) for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified rabies virus transsynaptic tracing strategy, we labeled neurons synapsing directly onto vibrissa facial motor neurons (vFMNs). Sources of potential excitatory, inhibitory, and modulatory vFMN premotor neurons, and differences between the premotor circuitry for vFMNs innervating intrinsic versus extrinsic vibrissal muscles were systematically characterized. The emergence of whisking is accompanied by the addition of new sets of bilateral excitatory inputs to vFMNs from neurons in the lateral paragigantocellularis (LPGi). Furthermore, descending axons from the motor cortex directly innervate LPGi premotor neurons. Thus, neural modules that are well suited to facilitate the bilateral coordination and cortical control of whisking are added to the premotor circuitry in parallel with the emergence of this exploratory behavior. Many vertebrates, including humans, acquire new behaviors during postnatal development. Using novel transsynaptic tracing techniques in mice, Takatoh et al. discover that new modules are added to vibrissal premotor circuitry in parallel with the postnatal emergence of exploratory whisking behavior.
机译：啮齿动物在出生后大约两周开始开始使用双边协调的，有规律的触须扫（“打扫”）进行环境探索。出生后振动控制电路是否（以及如何）改变尚不清楚，并且相关的运动前电路的特征仍然很差。使用改良的狂犬病病毒突触跟踪策略，我们标记了神经元直接突触到触须面部运动神经元（vFMNs）上。系统地表征了潜在的兴奋性，抑制性和调节性vFMN运动前神经元的来源，以及神经内源性和外在性振动的vFMNs的前运动电路之间的差异。搅拌的出现伴随有新的双边兴奋性输入集，这些新的双边兴奋性输入来自旁旁巨细胞细胞（LPGi）神经元的vFMN。此外，从运动皮质下降的轴突直接支配LPGi运动前神经元。因此，与这种探索行为的出现并行地，将非常适合于促进双侧协调和皮层搅拌控制的神经模块添加到前运动电路中。许多脊椎动物，包括人类在内，在产后发育过程中都会出现新的行为。 Takatoh等人在小鼠中使用新型的经突触追踪技术。发现在产后出现探索性搅拌行为的同时，向振动前运动回路添加了新模块。

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