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首页> 外文期刊>Neuron >Light-induced plasticity of synaptic ampa receptor composition in retinal ganglion cells
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Light-induced plasticity of synaptic ampa receptor composition in retinal ganglion cells

机译：视网膜神经节细胞中光诱导的突触安帕受体组成的可塑性

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Light-evoked responses of all three major classes of retinal ganglion cells (RGCs) are mediated by NMDA receptors (NMDARs) and AMPA receptors (AMPARs). Although synaptic activity at RGC synapses is highly dynamic, synaptic plasticity has not been observed in adult RGCs. Here, using patch-clamp recordings in dark-adapted mouse retina, we report a retina-specific form of AMPAR plasticity. Both chemical and light activation of NMDARs caused the selective endocytosis of GluA2-containing, Ca 2+-impermeable AMPARs on RGCs and replacement with GluA2-lacking, Ca 2+-permeable AMPARs. The plasticity was expressed in ON but not OFF RGCs and was restricted solely to the ON responses in ON-OFF RGCs. Finally, the plasticity resulted in a shift in the light responsiveness of ON RGCs. Thus, physiologically relevant light stimuli can induce a change in synaptic receptor composition of ON RGCs, providing a mechanism by which the sensitivity of RGC responses may be modified under scotopic conditions. Jones et al. report that AMPARs on retinal ganglion cells are dynamically regulated by light. The NMDAR-dependent removal of Ca 2+-impermeable and replacement with Ca 2+-permeable AMPARs underlies a mechanism of postsynaptic adaptation in the inner retina.
机译：视网膜神经节细胞（RGC）的所有三个主要类别的光诱发反应是由NMDA受体（NMDARs）和AMPA受体（AMPARs）介导的。尽管RGC突触的突触活性是高度动态的，但在成年RGC中尚未观察到突触可塑性。在这里，在黑暗适应的小鼠视网膜中使用膜片钳记录，我们报告了AMPAR可塑性的视网膜特定形式。 NMDAR的化学活化和光活化均引起RGC上含GluA2的，Ca 2+不可渗透的AMPAR的选择性内吞作用，并被缺乏GluA2的，具有Ca 2+的AMPAR替代。可塑性以ON表示，而不是OFF RGC表示，并且仅限于ON-OFF RGC的ON响应。最后，可塑性导致ON RGC的光响应性发生了变化。因此，生理相关的光刺激可以诱导ON RGC的突触受体组成发生变化，从而提供了一种机制，通过该机制可以在暗视条件下修饰RGC反应的敏感性。琼斯等。报告指出，视网膜神经节细胞上的AMPAR受光动态调节。 NMDAR依赖性的Ca 2+不可渗透去除和Ca 2+可渗透AMPAR的取代是内部视网膜中突触后适应的机制的基础。

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