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首页> 外文期刊>Neuron >Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators.
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Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators.

机译：过调节的GABA释放和丘脑皮层整合到新皮层兴奋性细胞中是由神经调节剂调节的。

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摘要

Neuromodulators such as acetylcholine, serotonin, and noradrenaline are powerful regulators of neocortical activity. Although it is well established that cortical inhibition is the target of these modulations, little is known about their effects on GABA release from specific interneuron types. This knowledge is necessary to gain a mechanistic understanding of the actions of neuromodulators because different interneuron classes control specific aspects of excitatory cell function. Here, we report that GABA release from fast-spiking (FS) cells, the most prevalent interneuron subtype in neocortex, is robustly inhibited following activation of muscarinic, serotonin, adenosine, and GABA(B) receptors--an effect that regulates FS cell control of excitatory neuron firing. The potent muscarinic inhibition of GABA release from FS cells suppresses thalamocortical feedforward inhibition. This is supplemented by the muscarinic-mediated depolarization of thalamo-recipient excitatory neurons and the nicotinic enhancement of thalamic input onto these neurons to promote thalamocortical excitation.
机译：神经调节剂如乙酰胆碱，5-羟色胺和去甲肾上腺素是新皮层活动的有力调节剂。尽管已经公认皮质抑制是这些调节的靶标，但对于它们对特定中间神经元类型释放GABA的影响知之甚少。由于对不同的中间神经元类别控制兴奋性细胞功能的特定方面，因此需要获得对神经调节剂作用的机械理解的知识。在这里，我们报告说，快速释放（FS）细胞（新皮层中最普遍的中间神经元亚型）释放的GABA在毒蕈碱，5-羟色胺，腺苷和GABA（B）受体激活后被强烈抑制-调节FS细胞的作用控制兴奋性神经元放电。从FS细胞释放的强毒蕈碱抑制GABA会抑制丘脑皮质前馈抑制。毒蕈碱介导的丘脑受体兴奋性神经元去极化和丘脑向这些神经元的尼古丁输入增强以促进丘脑皮质兴奋补充了这一点。

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