Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited.

Hata Y; Tsumoto T; Stryker MP

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Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited.

机译：当猫的视觉皮层在药理学上受到抑制时，对更多活性传入的选择性修剪。

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Activity-dependent competition is thought to guide the normal development of specific patterns of neural connections. Such competition generally favors more active inputs, making them larger and stronger, while less active inputs become smaller and weaker. We pharmacologically inhibited the activity of visual cortical cells and measured the three-dimensional structure of inputs serving the two eyes when one eye was occluded. The more active inputs serving the open eye actually became smaller than the deprived inputs from the occluded eye, which were similar to those in normal animals. These findings demonstrate in vivo that it is not the amount of afferent activity but the correlation between cortical and afferent activity that regulates the growth or retraction of these inputs.

机译：依赖活动的竞争被认为可以指导神经连接特定模式的正常发展。这种竞争通常倾向于积极主动的投入，使之变得更大和更强，而积极程度较小的投入则变得越来越小和减弱。我们在药理学上抑制了视觉皮层细胞的活性，并测量了一只眼睛被闭塞时为两只眼睛服务的输入的三维结构。实际上，为睁开眼睛服务的更活跃的输入变得比被闭塞的眼睛剥夺的输入小，这与正常动物的输入相似。这些发现在体内证明调节这些输入的生长或收缩的不是传入活性的量而是皮层和传入活性之间的相关性。

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《Neuron》 |1999年第2期|共7页
作者
Hata Y; Tsumoto T; Stryker MP;
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原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
GABA Agonists; Muscimol; Neural Inhibition; Neurons; Afferent; Visual Cortex; GABA激动剂; 蝇蕈醇; 神经抑制; 神经元; 传入; 视皮质;

机译：GABA Agonists;Muscimol;Neural Inhibition;Neurons;Afferent;Visual Cortex;GABA激动剂;蝇蕈醇;神经抑制;神经元;传入;视皮质;

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1. Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited. [J] . Hata Y, Tsumoto T, Stryker MP Neuron . 1999,第2期

机译：当猫的视觉皮层在药理学上受到抑制时，对更多活性传入的选择性修剪。
2. Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex [J] . Kondo Satoru, Ohki Kenichi Nature neuroscience . 2016,第2期

机译：小鼠初级视觉皮层膝状突入方向选择性的层流差异
3. On and off domains of geniculate afferents in cat primary visual cortex. [J] . Jin JZ, Weng C, Yeh CI, Nature neuroscience . 2008,第1期

机译：猫原发性视觉皮层中膝突传入和传出域。
4. Tuning properties of noisy cells with application to orientation selectivity in rat visual cortex [C] . Axel Etzold, Christian W. Eurich, Helmut Schwegler Computational neuroscience meeting . 2003

机译：大鼠视觉皮层中噪声细胞的调整特性
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Neural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited. [O] . H O Reiter, M P Stryker 1988

机译：没有突触后动作电位的神经可塑性：药理学上抑制小猫视觉皮层细胞时活性较低的输入成为主导。
7. Selective Pruning of More Active Afferents When Cat Visual Cortex Is Pharmacologically Inhibited [O] . Hata Yoshio, Tsumoto Tadaharu, Stryker Michael P 1999

机译：当猫视觉皮层被药理学抑制时，更多主动传入的选择性修剪

Selective pruning of more active afferents when cat visual cortex is pharmacologically inhibited.

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