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首页> 外文期刊>Neuron >Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons.
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Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons.

机译：亚单位规则支配海马神经元内在的AMPA受体的分类。

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摘要

Removal of synaptic AMPA receptors is important for synaptic depression. Here, we characterize the roles of individual subunits in the inducible redistribution of AMPA receptors from the cell surface to intracellular compartments in cultured hippocampal neurons. The intracellular accumulation of GluR2 and GluR3 but not GluR1 is enhanced by AMPA, NMDA, or synaptic activity. After AMPA-induced internalization, homomeric GluR2 enters the recycling pathway, but following NMDA, GluR2 is diverted to late endosomes/lysosomes. In contrast, GluR1 remains in the recycling pathway, and GluR3 is targeted to lysosomes regardless of NMDA receptor activation. Interaction with NSF plays a role in regulated lysosomal targeting of GluR2. GluR1/GluR2 heteromeric receptors behave like GluR2 homomers, and endogenous AMPA receptors show differential activity-dependent sorting similar to homomeric GluR2. Thus, GluR2 is a key subunit that controls recycling and degradation of AMPA receptors after internalization.
机译：去除突触AMPA受体对于突触抑制很重要。在这里，我们表征了在培养的海马神经元中从细胞表面到细胞内区室的AMPA受体的可诱导再分布中各个亚基的作用。 AMPA，NMDA或突触活性可增强GluR2和GluR3而不是GluR1的细胞内积累。在AMPA诱导的内在化之后，同源的GluR2进入回收途径，但在NMDA之后，GluR2转移至晚期的内体/溶酶体。相反，GluR1保留在回收途径中，而GluR3靶向溶酶体，而与NMDA受体的激活无关。与NSF的相互作用在GluR2的溶酶体靶向调控中发挥作用。 GluR1 / GluR2异聚受体的行为类似于GluR2同聚物，并且内源AMPA受体显示出与活性同分异构的GluR2相似的差异活性依赖型分类。因此，GluR2是内化后控制AMPA受体循环和降解的关键亚基。

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