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首页> 外文期刊>Neuron >Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF.
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Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF.

机译：果蝇GPCR Han是昼夜节律神经肽PDF的受体。

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摘要

The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named han, reduced the transcript level of CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain. han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of han null mutants were similar to those of pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons.
机译：色素分散因子（PDF）是控制果蝇昼夜节律行为节律的神经肽，但尚不清楚其受体。从果蝇的大规模温度偏好行为屏幕中，我们分离了一个P插入突变体，该突变体在白天和晚上都喜欢不同的温度。我们将这种突变称为han，降低了CG13758的转录水平。我们发现，汉族在成年大脑的13对昼夜节律时钟神经元中特异性表达。在持续不断的黑暗中，零果蝇表现出节律性昼夜节律行为。 han null突变体的行为特征与pdf null突变体的行为特征相似。我们还发现，PDF与表达Han的S2细胞特异性结合，从而导致cAMP合成的升高。因此，我们在本文中提出，Han是通过协调时钟神经元的活动来调节昼夜节律行为节律的PDF受体。

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