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首页> 外文期刊>Neuron >AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis.
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AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis.

机译：LTP期间将AMPA受体并入突触：横向运动和胞吐作用。

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摘要

The regulated trafficking of AMPA receptors (AMPARs) to synapses is thought to underlie the enhanced transmission in long-term potentiation (LTP), a cellular model of memory. However, there is controversy regarding the nonsynaptic site, either on the surface or intracellularly, from which AMPARs move into synapses during LTP. Using recombinant surface-fluorescent receptors in organotypic rat hippocampal slices, we show that the majority of AMPARs incorporated into synapses during LTP is from lateral diffusion of spine surface receptors containing GluR1, an AMPAR subunit. Following synaptic potentiation, AMPARs in intracellular pools containing GluR1 are driven to the surface primarily on dendrites. These exocytosed receptors likely serve to replenish the local extrasynaptic pool available for subsequent bouts of plasticity. These results clarify the role of intracellular and surface AMPARs during synaptic plasticity.
机译：据信，AMPA受体（AMPARs）到突触的受调节运输是长期增强（LTP）（一种记忆的细胞模型）中增强的传递的基础。但是，关于在表面或细胞内的非突触位点存在争议，在LTP期间，AMPAR从该位置进入突触。使用器官型大鼠海马切片中的重组表面荧光受体，我们显示LTP期间纳入突触的大多数AMPARs来自包含GluR1（一种AMPAR亚基）的脊柱表面受体的侧向扩散。突触增强后，包含GluR1的细胞内池中的AMPAR主要被驱动至树突上的表面。这些胞吐受体可能用来补充局部突触外池，可用于以后的可塑性发作。这些结果阐明了细胞内和表面AMPAR在突触可塑性中的作用。

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