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首页> 外文期刊>Neuron >From dendrite to soma: dynamic routing of inhibition by complementary interneuron microcircuits in olfactory cortex.
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From dendrite to soma: dynamic routing of inhibition by complementary interneuron microcircuits in olfactory cortex.

机译:从枝晶到体细胞:嗅觉皮层中互补性中间神经元微电路抑制的动态路由。

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摘要

Diverse inhibitory pathways shape cortical information processing; however, the relevant interneurons recruited by sensory stimuli and how they impact principal cells are unclear. Here we show that two major interneuron circuits govern dynamic inhibition in space and time within the olfactory cortex. Dendritic-targeting layer 1 interneurons receive strong input from the olfactory bulb and govern early-onset feedforward inhibition. However, this circuit is only transiently engaged during bursts of olfactory bulb input. In contrast, somatic-targeting layer 3 interneurons, recruited exclusively by recurrent excitation from pyramidal cells, produce late-onset feedback inhibition. Our results reveal two complementary interneuron circuits enforcing widespread inhibition, which shifts from the apical dendrites to somata of pyramidal cells during bursts of sensory input.
机译:多种抑制途径影响皮层信息处理。然而,尚不清楚由感觉刺激募集的相关中间神经元以及它们如何影响主细胞。在这里,我们显示了两个主要的中间神经元回路控制嗅觉皮质内空间和时间的动态抑制。靶向树突的第1层神经元从嗅球获得大量输入,并控制早发性前馈抑制。然而,该电路仅在嗅觉灯泡输入的突发期间短暂地接合。相比之下,体细胞靶向层3中间神经元仅通过反复刺激从锥体细胞中募集,产生迟发的反馈抑制作用。我们的研究结果揭示了两个互补的中间神经元回路,其执行广泛的抑制作用,在感觉输入的爆发过程中,它们从顶突转变为锥体细胞的体细胞。

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