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首页> 外文期刊>Neuropharmacology >Regulation of drug-taking and -seeking behaviors by neuroadaptations in the mesolimbic dopamine system.
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Regulation of drug-taking and -seeking behaviors by neuroadaptations in the mesolimbic dopamine system.

机译：中脑边缘多巴胺系统中的神经适应对药物吸收和寻求行为的调节。

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Previous studies have identified several neuroadaptations to chronic drug use, but relatively few have been functionally linked to addiction-related changes in drug-taking and -seeking behaviors. This article summarizes our past and present studies on the contribution of drug-induced neuroadaptations in the mesolimbic dopamine system to addiction-related changes in drug self-administration and the propensity for relapse in drug withdrawal. Our studies suggest that drug-induced up-regulation in cyclic AMP (cAMP)-protein kinase A (PKA) signaling in the nucleus accumbens (NAc) contributes to escalating drug intake and a propensity for relapse by differentially altering the sensitivity of D(1) and D(2) dopamine receptors that regulate drug-taking and -seeking behaviors. In addition, our studies suggest that drug-induced neuroplasticity at excitatory synapses in both the ventral tegmental area (VTA) and the NAc also facilitates drug-seeking behavior and the propensity for relapse. Finally, the role of both transient and enduring neuroadaptations in regulating drug-seeking behavior is discussed in view of different learning- and memory-based interactions.
机译：先前的研究已经确定了对慢性药物使用的几种神经适应性，但是在功能上与吸毒和寻求行为上瘾成瘾相关的变化相关。本文总结了我们过去和现在的研究，这些研究涉及中脑边缘多巴胺系统中药物诱导的神经适应对成瘾相关药物自我管理的改变和戒断的复发倾向的影响。我们的研究表明药物诱导伏隔核（NAc）中的环AMP（cAMP）-蛋白激酶A（PKA）信号转导的上调通过差异地改变D（1 ）和D（2）多巴胺受体，它们调节药物的吸收和寻求行为。此外，我们的研究表明，在腹侧被盖区（VTA）和NAc的兴奋性突触中，药物诱导的神经可塑性也促进了药物寻找行为和复发倾向。最后，针对不同的基于学习和记忆的相互作用，讨论了暂时性和持久性神经适应在调节药物寻找行为中的作用。

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