...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuropharmacology >Reversal of learned helplessness by selective serotonin reuptake inhibitors in rats is not dependent on 5-HT availability.
【24h】

Reversal of learned helplessness by selective serotonin reuptake inhibitors in rats is not dependent on 5-HT availability.

机译：选择性5-羟色胺再摄取抑制剂在大鼠中逆转所习得的无助感并不取决于5-HT的可用性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Serotonin (5-HT) and 5-HT(1A) receptors have been suggested to play a pivotal role in the mechanism of action of antidepressant drugs, particularly in the case of selective serotonin reuptake inhibitors (SSRIs). In the rat learned helplessness (LH) paradigm, a valid animal model of human depression, repeated treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT (0.125 and 0.5mg/kg) and several classes of antidepressants such as the tricyclic agent desipramine (30 and 60mg/kg), the monoamine oxidase inhibitor (MAOI) pargyline (60mg/kg) and the SSRIs fluoxetine (15 and 30mg/kg), paroxetine (15 and 30mg/kg) and sertraline (30mg/kg) improved behavioural deficit in helpless rats. The involvement of serotonergic mechanisms in the antidepressant-like effect of these agents was investigated using the selective 5-HT(1A) receptor antagonist WAY 100,635 and the 5-HT synthesis inhibitor p-chlorophenylalanine (PCPA). Pretreatment with WAY 100,635 blocked the 8-OH-DPAT-induced reduction in escape failures, but did not counteract the antidepressant effect of fluoxetine and paroxetine. PCPA given alone did not modify helpless behaviour nor did it affect the behavioural effect of 8-OH-DPAT, fluoxetine and paroxetine. Adaptive changes in 5-HT(1A) receptor function were studied by measuring 8-OH-DPAT-mediated hypothermia and lower lip retraction (LLR) in the animals 24h after LH test session. Fluoxetine and paroxetine treatments caused a marked reduction in agonist-induced responses, an effect completely prevented by WAY 100,635 and PCPA. In conclusion, whereas direct agonist activity at postsynaptic 5-HT(1A) receptors attenuated helpless behaviour, the antidepressant-like effect of SSRIs was found to be independent of their actions on either 5-HT(1A) receptor function or extracellular 5-HT.
机译：有人建议血清素（5-HT）和5-HT（1A）受体在抗抑郁药的作用机制中起着关键作用，特别是在选择性5-羟色胺再摄取抑制剂（SSRI）的情况下。在大鼠学习到的无助（LH）范例中，这是一种有效的人类抑郁症动物模型，使用5-HT（1A）受体激动剂8-OH-DPAT（0.125和0.5mg / kg）以及几种抗抑郁药反复治疗三环制剂地昔帕明（30和60mg / kg），单胺氧化酶抑制剂（MAOI）Pargyline（60mg / kg）和SSRIs氟西汀（15和30mg / kg），帕罗西汀（15和30mg / kg）和舍曲林（30mg / kg）公斤）改善了无助大鼠的行为缺陷。使用选择性5-HT（1A）受体拮抗剂WAY 100,635和5-HT合成抑制剂对氯苯丙氨酸（PCPA）研究了血清素能机制参与这些药物的抗抑郁样作用。用WAY 100,635预处理可阻止8-OH-DPAT诱导的逃逸失败率降低，但不能抵消氟西汀和帕罗西汀的抗抑郁作用。单独给予PCPA不会改变无助行为，也不会影响8-OH-DPAT，氟西汀和帕罗西汀的行为效果。在LH测试后的24小时内，通过测量8-OH-DPAT介导的体温过低和下唇缩回（LLR），研究了5-HT（1A）受体功能的适应性变化。氟西汀和帕罗西汀治疗显着降低了激动剂诱导的反应，这一作用被WAY 100,635和PCPA完全阻止。总之，虽然对突触后5-HT（1A）受体的直接激动剂活性减弱了无助行为，但发现SSRI的抗抑郁样作用与其对5-HT（1A）受体功能或细胞外5-HT的作用无关。 。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号