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首页> 外文期刊>Neurophysiology >Biophysical Mechanism of Parasympathetic Excitation of Urinary Bladder Smooth Muscle Cells: a Simulation Study
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Biophysical Mechanism of Parasympathetic Excitation of Urinary Bladder Smooth Muscle Cells: a Simulation Study

机译：副膀胱交感神经兴奋膀胱平滑肌细胞的生物物理机制：模拟研究

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摘要

Using the Hodgkin-Huxley formalism, we developed a computer model of a smooth muscle cell (SMC) of the urinary bladder detrusor; the model included the main types of ion channels and pumps, as well as intracellular calcium regulatory mechanisms inherent in the prototype cell. The biophysical mechanisms of generation of action potentials (APs) necessary for initiation of muscle contraction and those of calcium transients in response to parasympathetic activation of metabotropic De2/De3-cholinoreceptors and co-activation of D 2Dyen-purinoreceptors were investigated. The simulated SMC in response to a depolarizing current pulse generated an AP that was, by a number of indices, similar to real APs and was also accompanied by a transient elevation of the intracellular calcium concentration. We demonstrated a possibility of generation of such APs in response to a transient increase in the conductivity of channels of calcium-dependent chloride current accompanied by increase in the conductivity of channels associated with D 2Dyen-receptors (the conductivity ratio was 95 to 5 % and similar to that in the prototype). For the AP generation, temporal relations of the processes of increases in the mentioned conductances simulating the final effect of activation of De2/De3- and D 2Dyen-receptors were significant. These results obtained on the rather simplified model allow researchers to use the latter as an appropriate starting point for the development of more detailed models (in particular, those representing cascades of metabolic reactions triggered by a parasympathetic action).
机译：使用Hodgkin-Huxley形式主义，我们开发了膀胱逼尿肌平滑肌细胞（SMC）的计算机模型;该模型包括离子通道和泵的主要类型，以及原型细胞固有的细胞内钙调节机制。研究了产生肌肉收缩的动作电位（APs）的生物物理机制，以及响应代谢型De2 / De3-胆碱受体的副交感神经激活和D 2Dyen-嘌呤受体的共激活所引起的钙瞬变的生物物理机制。响应去极化电流脉冲，模拟的SMC生成的AP在许多指标上均与真实的AP相似，并且还伴随着细胞内钙浓度的瞬时升高。我们证明了响应于钙依赖性氯离子电流通道电导率的瞬时增加并伴随与D 2Dyen受体相关的通道电导率的增加而产生此类AP的可能性（电导率为95％至5％，与原型相似）。对于AP的产生，所述电导的增加过程的时间关系是模拟De2 / De3-和D 2Dyen受体激活的最终效果的时间关系。在相当简化的模型上获得的这些结果使研究人员可以将后者用作开发更详细模型的合适起点（尤其是那些代表副交感神经作用触发的代谢反应级联的模型）。

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