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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: Astudy among patients with subcortical vascular cognitive impairment
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Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: Astudy among patients with subcortical vascular cognitive impairment

机译：APOEε4对脑淀粉样蛋白，腔隙性梗塞和白质病变的影响：皮层下血管性认知障碍患者的研究

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摘要

The relationship between the apolipoprotein E ε4 allele (APOE4) and factors associated with vascular cognitive impairment (VCI) is unclear. We aimed to examine the effects of APOE4 on brain amyloid beta using Pittsburg compound B (PiB) and subcortical cerebrovascular disease, as assessed by lacunes and white matter hyperintensities (WMH) in subcortical VCI (SVCI) patients. We recruited 230 subjects with normal cognition, 111 subjects with cognitive impairment due to clinically defined Alzheimer's disease (ADCI), and 134 subjects with clinically defined SVCI. A PiB retention ratio greater than 1.5 was considered to be PiB positive. Logistic regression analysis was performed to investigate whether APOE4 increased the risk for each cognitive impairment group. Multiple linear regression analysis was performed to investigate whether APOE4 was associated with brain amyloid beta, lacunes, and WMH. APOE4 did not increase the risk of PiB(-) SVCI (odds ratio [OR], 1.50; 95% confidence interval [CI], 0.79-2.84), whereas APOE4 increased the risk of PiB(+) SVCI (OR, 4.52; 95% CI, 1.70-11.97) and PiB(+) ADCI (odds ratio, 4.84; 95% CI, 2.54-7.91). In SVCI patients, APOE4 was positively associated with PiB retention ratio, whereas APOE4 was not associated with the number of lacunes or with WMH volume. Our results suggest that amyloid beta burden can occur in patients with and without subcortical cerebrovascular disease, and that it is associated with APOE4. However APOE4 might be independent of subcortical cerebrovascular disease.
机译：载脂蛋白Eε4等位基因（APOE4）与与血管性认知障碍（VCI）相关的因素之间的关系尚不清楚。我们旨在检查匹兹堡化合物B（PiB）和皮层下脑血管疾病对APOE4对脑淀粉样蛋白β的作用，并通过皮层下VCI（SVCI）患者的腔隙和白质高强度（WMH）进行评估。我们招募了230名具有正常认知能力的受试者，111名因临床定义为阿尔茨海默氏病（ADCI）而导致的认知障碍受试者和134名具有临床定义的SVCI受试者。 PiB保留率大于1.5被认为是PiB阳性。进行逻辑回归分析以调查APOE4是否增加了每个认知障碍组的风险。进行了多元线性回归分析，以调查APOE4是否与脑淀粉样蛋白，内酰胺和WMH相关。 APOE4并未增加PiB（-）SVCI的风险（几率[OR]为1.50; 95％置信区间[CI]为0.79-2.84），而APOE4却增加了PiB（+）SVCI的风险（OR为4.52; 95％CI，1.70-11.97）和PiB（+）ADCI（赔率，4.84; 95％CI，2.54-7.91）。在SVCI患者中，APOE4与PiB保留率呈正相关，而APOE4与腔隙数或WMH量无关。我们的结果表明，淀粉样蛋白β负担可以在有或没有皮质下脑血管疾病的患者中发生，并且与APOE4相关。但是，APOE4可能独立于皮层下脑血管疾病。

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