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首页> 外文期刊>Neuropsychobiology >Serotonin Dysfunction and Suicide Attempts in Major Depressives: An Auditory Event-Related Potential Study.
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Serotonin Dysfunction and Suicide Attempts in Major Depressives: An Auditory Event-Related Potential Study.

机译：重大抑郁症患者的5-羟色胺功能障碍和自杀尝试：与听觉事件相关的潜在研究。

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Background: Serotonergic dysfunction is believed to be involved in suicide attempts. The loudness-dependent auditory evoked potential (LDAEP) is one of the validated indicators of the activity of the central serotonin system in humans. Objectives: This study was designed to investigate possible differences in the LDAEP and P300 between those depressed patients who attempted suicide and those who did not. Methods: The LDAEP and P300 levels were recorded for 66 depressive patients (among which 16 had attempted suicide). Results: Those who had attempted suicide showed a sharper slope of the LDAEP and increased frontal P300 amplitude. A high correlation between the LDAEP and P300, and a gender difference were also noted. Conclusions: Our results are concordant with previous assumptions about serotonin dysfunction in depressives who attempt suicide. Copyright (c) 2005 S. Karger AG, Basel.
机译：背景：血清素能功能障碍被认为与自杀企图有关。响度依赖性听觉诱发电位（LDAEP）是人类中枢5-羟色胺系统活性的有效指标之一。目的：本研究旨在调查尝试自杀的抑郁患者和未自杀的抑郁患者之间LDAEP和P300的可能差异。方法：记录66名抑郁症患者（其中16名自杀未遂）的LDAEP和P300水平。结果：自杀未遂者的LDAEP斜率更大，额叶P300振幅增加。还注意到LDAEP和P300之间存在高度相关性，并且存在性别差异。结论：我们的结果与先前关于自杀企图的抑郁症患者血清素功能异常的假设一致。版权所有（c）2005 S.Karger AG，巴塞尔。

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