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首页> 外文期刊>Neuropsychologia >Stimulation at dorsal and ventral electrode contacts targeted at the subthalamic nucleus has different effects on motor and emotion functions in Parkinson's disease.
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Stimulation at dorsal and ventral electrode contacts targeted at the subthalamic nucleus has different effects on motor and emotion functions in Parkinson's disease.

机译：针对丘脑下核的背侧和腹侧电极接触的刺激对帕金森氏病的运动和情绪功能有不同的影响。

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摘要

Motor and emotion processing depend on different fronto-basal ganglia circuits. Distinct sub-regions of the subthalamic nucleus (STN) may modulate these circuits. We evaluated whether stimulation targeted at separate territories in the STN region would differentially affect motor and emotion function. In a double-blind design, we studied twenty Parkinson's disease patients who had deep brain stimulation (DBS) electrodes implanted bilaterally in the STN. We stimulated either dorsal or ventral contacts of the STN electrodes on separate days in each patient and acquired behavioral measures. Dorsal contact stimulation improved motor function by reducing scores on the Unified Parkinson's Disease Rating Scale and by reducing both reaction time and reaction time variability compared to ventral contact stimulation. By contrast, ventral contact stimulation led to an increase in positive emotion compared to dorsal contact stimulation. These results support the hypothesis that different territories within the STN region implement motor and emotion functions.
机译：运动和情绪处理取决于不同的额基底神经节回路。丘脑底核（STN）的不同子区域可能会调制这些电路。我们评估了针对STN区域中不同区域的刺激是否会不同地影响运动和情绪功能。在双盲设计中，我们研究了二十名帕金森氏病患者，他们在双侧STN两侧植入了深部脑刺激（DBS）电极。我们在每位患者的不同天内刺激了STN电极的背侧或腹侧接触，并获得了行为措施。与腹侧接触刺激相比，背侧接触刺激通过降低统一帕金森氏病评分量表的得分，并通过减少反应时间和反应时间可变性来改善运动功能。相比之下，与背侧接触刺激相比，腹侧接触刺激导致积极情绪增加。这些结果支持以下假设：STN区域内的不同领土实现了运动和情绪功能。

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