GABAergic synapses on mu-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord.

Gong LW; Ding YQ; Wang D; Zheng HX; Qin BZ; Li JS; Kaneko T; Mizuno N

首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >GABAergic synapses on mu-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord.

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GABAergic synapses on mu-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord.

机译：浅表背角中表达阿片受体的神经元的GABA能突触：在猫脊髓中的电子显微镜研究。

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A double-immunocytochemical electron microscope study was performed in the cat to examine whether GABAergic axons might be in synaptic contact with spinal neurons expressing mu-opioid receptor (MOR) in laminae I and II of the spinal dorsal horn at the lumbar cord segments. Structures showing MOR-like immunoreactivity (-LI) and those showing GABA-LI were labeled, respectively, with diaminobenzidine/peroxidase-reaction products and immunogold particles. Approximately one-third of dendritic profiles with MOR-LI in laminae I and II were postsynaptic to axon terminals with GABA-LI; about one-fourth of somatic profiles with MOR-LI were also postsynaptic to axon terminals with GABA-LI. The results suggest that activation of MOR on postsynaptic neurons may modulate effects which are induced by GABA released from presynaptic neurons.

机译：在猫中进行了双免疫细胞化学电子显微镜研究，以检查GABA能轴突是否可能与腰椎节段脊髓背角的I和II层中表达mu阿片受体（MOR）的脊髓神经元发生突触接触。用二氨基联苯胺/过氧化物酶反应产物和免疫金颗粒分别标记显示出MOR样免疫反应性（-LI）和显示出GABA-LI的结构。在第I和第II层中，MOR-LI的约三分之一的树突状分布在GABA-LI的突触后突触到轴突末端。 MOR-LI的约四分之一的体细胞分布图也与GABA-LI的轴突末端突触后。结果表明，MOR在突触后神经元上的激活可能调节由突触前神经元释放的GABA诱导的效应。

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《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 |1997年第1期|共4页
作者
Gong LW; Ding YQ; Wang D; Zheng HX; Qin BZ; Li JS; Kaneko T; Mizuno N;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Neurons; Receptors; Opioid; mu; Spinal Cord; Synapses; gamma-Aminobutyric Acid; 神经元; 受体; 阿片样; μ; 脊髓; 突触;

机译：Neurons;Receptors;Opioid;mu;Spinal Cord;Synapses;gamma-Aminobutyric Acid;神经元;受体;阿片样;μ;脊髓;突触;

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1. GABAergic synapses on mu-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord. [J] . Gong LW, Ding YQ, Wang D, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1997,第1期

机译：浅表背角中表达阿片受体的神经元的GABA能突触：在猫脊髓中的电子显微镜研究。
2. Localization of a metabotropic glutamate receptor, mGluR7, in axon terminals of presumed nociceptive, primary afferent fibers in the superficial layers of the spinal dorsal horn: an electron microscope study in the rat. [J] . Li H, Ohishi H, Kinoshita A, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 1997,第3期

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3. PHYSIOLOGICAL AND MORPHOLOGICAL CHARACTERISTICS OF NEURONS IN SUPERFICIAL DORSAL HORN OF CAT SPINAL CORD: AN INTRACELLULAR STUDY IN VIVO [J] . HAN ZHONG-SHENG Chinese Journal of Physiological Sciences . 1995,第2期

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4. Cellular Mechanisms for the Enhancement by Bee Venom Melittin of GABAergic and Glycinergic Inhibitory Synaptic Transmission in Adult Rat Spinal Dorsal Horn Neurons [C] . Tao Liu, Tsugumi Fujita, Hai-Yuan Yue Japanese peptide symposium . 2010

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5. Modulation of gamma-aminobutyric acid (GABA) type A receptor-mediated responses in spinal dorsal horn neurons by mu-opioid receptor agonists and calcium(2+)/calmodulin-dependent protein kinase and Monte Carlo simulation of the GABAergic synaptic transmission. [D] . Wang, Rong. 1995

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6. Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation [O] . Tomonori Takazawa, Papiya Choudhury, Chi-Kun Tong, 2017

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GABAergic synapses on mu-opioid receptor-expressing neurons in the superficial dorsal horn: an electron microscope study in the cat spinal cord.

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