• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >Gene expression in autonomic areas of the medulla and the central nucleus of the amygdala in rats during and after space flight.
【24h】

Gene expression in autonomic areas of the medulla and the central nucleus of the amygdala in rats during and after space flight.

机译：航天飞行中和飞行后大鼠髓质和杏仁核中央核自主区的基因表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

During space flight astronauts show vestibular-related changes in balance, eye movements, and spontaneous and reflex control of cardiovascular, respiratory and gastrointestinal function, sometimes associated with space motion sickness. These symptoms undergo compensation over time. Here we used changes in the expression of two immediate-early gene (IEG) products to identify cellular and molecular changes occurring in autonomic brainstem regions of adult male albino rats killed at different times during the Neurolab Space Mission (STS-90). Both direct effects of gravitational changes, as well as indirect effects of gravitational changes on responses to light exposure were examined. Regions under the direct control of vestibular afferents such as the area postrema and the caudal part of the nucleus of the tractus solitarius (NTSC) were both directly and indirectly affected by gravity changes. These areas showed no changes in the expression of IEG products during exposure to microgravity with respect to ground controls, but did show a significant increase 24 h after return to 1 G (gravity). Exposure to microgravity significantly inhibited gene responses to light exposure seen after return to 1 G. A similar direct and indirect response pattern was also shown by the central nucleus of the amygdala, a basal forebrain structure anatomically and functionally related to the NTS. The rostral part of the NTS (NTSR) receives different afferent projections than the NTSC. This region did not show any direct gravity-related changes in IEG expression, but showed an indirect effect of gravity on IEG responses to light. A similar pattern was also obtained in the intermediate reticular nucleus and the parvocellular reticular nucleus. Two other medullary reticular structures, the dorsal and the ventral medullary reticular nuclei showed a less well defined pattern of responses that differed from those seen in the NTSC and NTSR. The short- and long-lasting molecular changes in medullary and basal forebrain gene expression described here are thought to play an important role in the integration of autonomic and vestibular signals that ultimately regulate neural adaptations to space flight.
机译：在太空飞行期间，宇航员表现出前庭相关的平衡变化，眼球运动以及对心血管，呼吸和胃肠功能的自发性和反射性控制，有时还伴有空间晕动病。这些症状会随着时间的流逝而得到补偿。在这里，我们使用了两个即刻早期基因（IEG）产品表达的变化来确定在Neurolab太空任务（STS-90）的不同时间被杀死的成年雄性白化病大鼠的自主脑干区域中发生的细胞和分子变化。研究了重力变化的直接影响以及重力变化对曝光响应的间接影响。重力变化直接或间接影响前庭传入直接控制的区域，例如后区域和孤束核（NTSC）的尾部。这些区域相对于地面对照显示在微重力作用下IEG产物的表达没有变化，但是在返回1 G（重力）后24小时确实显示出明显的增加。微重力暴露显着抑制了基因回复到1 G后对光照的响应。杏仁核的中央核也显示了相似的直接和间接响应模式，杏仁核是在解剖学上和功能上与NTS相关的基础前脑结构。 NTS（NTSR）的鸟嘴部分接收的投影不同于NTSC。该区域在IEG表达中未显示任何与重力有关的直接变化，但显示了重力对IEG对光的响应的间接影响。在中间网状核和小细胞网状核中也获得了相似的模式。其余两个网状网状结构，背侧和腹侧网状网状核显示的反应模式定义不太明确，与NTSC和NTSR不同。人们认为此处所述的延髓和基底前脑基因表达的短期和长期分子变化在自主神经和前庭信号的整合中起着重要作用，这些信号最终调节了神经对太空飞行的适应性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号