The many roles of microRNAs in brain tumor biology

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The many roles of microRNAs in brain tumor biology

机译：microRNA在脑肿瘤生物学中的许多作用

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MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics.

机译：MicroRNA（miRNA）现在被认为是故意沉默细胞自身信息的主要RNA。除了已确定miRNA作为正常细胞功能的发育调节剂的作用外，最近还发现它们在诸如癌症等病理状态中起重要作用。作者回顾了有关miRNA在神经胶质瘤和髓母细胞瘤形成和繁殖中作用的文献，强调了这些分子及其抑制剂作为治疗剂的潜力。

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《Neurosurgical focus》 |2010年第1期|共1页
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正文语种 eng
中图分类外科学;
关键词
Cancer stem cell; Glioma; Medulloblastoma; MicroRNA;

机译：癌症干细胞;神经胶质瘤;成神经细胞瘤;MicroRNA;

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专利

1. The many roles of microRNAs in brain tumor biology [J] . Neurosurgical focus . 2010,第1期

机译：microRNA在脑肿瘤生物学中的许多作用
2. Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors [J] . Bronisz Agnieszka, Godlewski Jakub, Chiocca E. Antonio Cellular and Molecular Neurobiology . 2016,第3期

机译：细胞外囊泡和MicroRNA：在肿瘤发生和脑肿瘤治疗中的作用。
3. In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies [J] . Iva Simeonova, Emmanuelle Huillard Cellular and molecular life sciences: CMLS . 2014,第20期

机译：脑肿瘤的体内模型：基因工程小鼠模型在理解肿瘤生物学及其在临床前研究中的作用
4. Studying the MicroRNA Role as a Survival Predictor and Revealing Its Part in Malignancy Level Determination in Patients with Supratentorial Gliomas of Brain [C] . E. V. Stupak, Yu. A. Veryaskina, S. E. Titov, International Conference on Physics of Cancer : Interdisciplinary Problems and Clinical Applications . 2017

机译：研究MicroRNA作用作为生存预测因子，并揭示脑外脑病患者的恶性水平测定部分
5. Targeting determinants of aggressiveness in malignant brain tumors: the role of hDRR-1 in glioma invasion and Wnt signaling in medulloblastoma biology. [D] . de Oliveira, Roberta. 2010

机译：针对恶性脑肿瘤侵袭性的目标决定因素：hDRR-1在神经胶质瘤侵袭中的作用和髓母细胞瘤生物学中的Wnt信号传导。
6. In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies [O] . Iva Simeonova, Emmanuelle Huillard -1

机译：脑肿瘤的体内模型：基因工程小鼠模型在理解肿瘤生物学及其在临床前研究中的作用
7. In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies [O] . 2014

机译：脑肿瘤的体内模型：基因工程小鼠模型在理解肿瘤生物学及其在临床前研究中的作用

The many roles of microRNAs in brain tumor biology

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