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首页> 外文期刊>Nordic journal of psychiatry. >Contingent negative variation in patients with deficit schizophrenia or bipolar I disorder with psychotic features: Measurement and correlation with clinical characteristics
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Contingent negative variation in patients with deficit schizophrenia or bipolar I disorder with psychotic features: Measurement and correlation with clinical characteristics

机译：精神分裂症缺陷型精神分裂症或双相I型障碍患者的或有负性变化：测量值及其与临床特征的关系

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Background: Schizophrenia is a highly heterogeneous disease. Event-related potentials have been regarded to establish intermediate phenotypes of schizophrenia. Our previous study found that patients with deficit schizophrenia (DS) are relatively homogeneous and show a significantly longer onset latency of contingent negative variation (CNV) expectancy wave. Aims: To further examine CNV in patients with first-episode and drug-naive DS or bipolar I disorder (BP I) with psychotic features, and also investigate correlations between CNV and clinical characteristics in DS and BP I. Method: We elicited a CNV using an alarm (S1)-imperative (S2) paradigm in 30 DS patients or 33 BP I with psychotic features as well as 40 healthy controls. Results: CNV amplitude was significantly smaller and reaction time significantly longer in the DS and BP I groups than in healthy controls. Post-imperative negative variation (PINV) interval was significantly shorter in the DS group than in healthy controls. The onset latency of CNV expectancy wave was significantly longer and PINV area significantly smaller in the DS group than in the other groups. In the DS group, CNV amplitude and PINV interval correlated negatively with the subscale of negative symptoms on the Positive and Negative Syndrome Scale (PANSS); CNV amplitude also correlated negatively with disease duration. In the BP I group, CNV amplitude and reaction time showed no correlation with clinical features. Conclusions: CNV amplitude is a common trait marker for psychosis. The onset latency of CNV expectancy wave appears to be a specific trait marker and may be used to identify candidate genes for DS.
机译：背景：精神分裂症是一种高度异质性疾病。事件相关电位已被认为可以建立精神分裂症的中间表型。我们先前的研究发现，精神分裂症缺陷症（DS）的患者相对均一，并且显示偶然性负变异（CNV）预期波的发作潜伏期明显更长。目的：进一步检查具有精神病性特征的首发和单纯药物性DS或双相I障碍（BP I）患者的CNV，并研究CNV与DS和BP I临床特征之间的相关性。方法：我们引出了CNV在30名具有精神病特征的DS患者或33名BP I患者中使用了警报（S1）-命令式（S2）范例，以及40名健康对照者。结果：与健康对照组相比，DS和BP I组的CNV幅度明显较小，反应时间明显更长。 DS组的命令后阴性变化（PINV）间隔明显短于健康对照组。与其他组相比，DS组中CNV期望波的发作潜伏期明显更长，而PINV面积明显更小。在DS组中，CNV幅度和PINV间隔与阳性和阴性综合征量表（PANSS）上的阴性症状子量表负相关; CNV振幅也与疾病持续时间负相关。在BP I组中，CNV振幅和反应时间与临床特征无关。结论：CNV振幅是精神病的常见特征标记。 CNV期望波的起始潜伏期似乎是一种特定的性状标记，可用于识别DS的候选基因。

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