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首页> 外文期刊>Nordic journal of psychiatry. >Cognition and HPA axis reactivity in mildly to moderately depressed outpatients. A case-control study
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Cognition and HPA axis reactivity in mildly to moderately depressed outpatients. A case-control study

机译：轻度至中度抑郁的门诊患者的认知和HPA轴反应性。病例对照研究

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Background: Patients with depression display neurobiological changes of the hypothalamicpituitary axis as well as cognitive disturbances. Aims: To assess any association between hypothalamuspituitaryadrenal (HPA) axis reactivity and memory-related cognitive functions. Methods: Depressed outpatients (n 83, ICD-10) were group-matched to healthy controls (n 33), and tested on a number of cognitive domains. Salivary samples were collected at awakening, 30 min later and at 22:00 h. At 23:00 h, the participants ingested 1.0 mg of dexamethasone, and three saliva samples were collected the following day at the same times. Results: Patients and controls did not differ on any memory-related cognitive skills. After dexamethasone the cortisol level was 1.7 nmol/l higher (95% CI 0.02.8, P 0.05) in depressed patients compared with controls. In the control group, but not in the patients, a positive association between post-DST cortisol and Rey's Complex figure test (1.3; 95% CI 0.33.6; P 0.02) was found. We found no significant associations between other memory functions and cortisol measures. Conclusions: Contrary to our hypothesis, we found a positive association between cortisol levels after dexamethasone and visuo-spatial memory primarily driven by the healthy controls. Otherwise, no association were found between HPA axis reactivity and memory-related cognitive function.
机译：背景：患有抑郁症的患者表现出下丘脑垂体轴的神经生物学变化以及认知障碍。目的：评估下丘脑垂体肾上腺（HPA）轴反应性与记忆相关的认知功能之间的任何关联。方法：将抑郁症的门诊患者（83例，ICD-10）与健康对照者（33例）进行分组配对，并在多个认知领域进行测试。唤醒，30分钟后和22:00小时收集唾液样品。在23:00 h，参与者摄入了1.0 mg地塞米松，第二天第二天同时采集了三个唾液样本。结果：患者和对照组在记忆相关的认知技能上没有差异。与对照组相比，地塞米松治疗后抑郁患者的皮质醇水平高1.7 nmol / l（95％CI 0.02.8，P 0.05）。在对照组而非患者中，发现DST后皮质醇与Rey's Complex身材测验之间呈正相关（1.3; 95％CI 0.33.6; P 0.02）。我们发现其他记忆功能和皮质醇措施之间没有重大关联。结论：与我们的假设相反，我们发现地塞米松治疗后的皮质醇水平与主要由健康对照组驱动的视觉空间记忆之间存在正相关。否则，在HPA轴反应性和记忆相关的认知功能之间未发现关联。

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