• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nordic journal of psychiatry. >SSRIs and risk of suicide attempts in young people - A Danish observational register-based historical cohort study, using propensity score
【24h】

SSRIs and risk of suicide attempts in young people - A Danish observational register-based historical cohort study, using propensity score

机译：SSRIs和年轻人自杀未遂的风险-基于倾向评分的丹麦观察性登记历史队列研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: SSRIs are widely used in the treatment of mental illness for both children and adults. Studies have found a slightly increased risk of suicidal thoughts and suicide attempts in young people using SSRIs but SSRIs' impact on risk for suicides in youth is not well-established. Aim: Is there indication that SSRIs might raise risk for suicide attempts in young people? Methods: We used an observational register-based historical cohort design, a large cohort of all Danish individuals born in 1983-1989 (n = 392,458) and a propensity score approach to analyse the impact from SSRIs on risk for suicide attempts. Every suicide attempt and redeemed prescription of SSRIs was analysed by Cox regression. Results: We found a significant overlap between redeeming a prescription on SSRIs and subsequent suicide attempt. The risk for suicide attempt was highest in the first 3 months after redeeming the first prescription. The hazard ratio for suicide attempts after redeeming a prescription was estimated to 5.23, 95% CI 4.82-5.68. Conclusion: We conclude that the risk of suicide attempt is higher for young people in the first months after redeeming their first prescription for SSRIs, compared to non-users. For SSRI users with lower propensity score (fewer risk factors for SSRIs) the risk of suicide attempt is estimated to be highest. Although the design may miss some explicit reason for prescription of SSRIs and SSRIs might be a marker for those in high risk rather than a causal risk factor, we would recommend systematic risk assessment in the period after redeeming the first prescription.
机译：背景：SSRIs广泛用于儿童和成人的精神疾病治疗。研究发现，使用SSRI的年轻人有自杀念头和自杀未遂的风险略有增加，但是SSRI对青年自杀风险的影响尚不充分。目的：是否有迹象表明SSRI可能会增加年轻人自杀未遂的风险？方法：我们采用基于观察者登记的历史队列设计，所有1983年至1989年出生的丹麦个体的大型队列（n = 392,458）和倾向评分法来分析SSRI对自杀未遂风险的影响。通过Cox回归分析SSRI的每一次自杀尝试和赎回处方。结果：我们发现在赎回SSRI处方与随后的自杀未遂之间存在重大重叠。赎回第一个处方后的头三个月内自杀未遂的风险最高。赎回处方后自杀未遂的危险比估计为5.23，95％CI 4.82-5.68。结论：我们得出的结论是，赎回SSRI的第一个处方后，年轻人的自杀未遂风险要高于非使用者。对于倾向评分较低（SSRI危险因素较少）的SSRI用户，自杀未遂的风险估计最高。尽管设计可能会遗漏某些明确规定使用SSRI的理由，并且SSRI可能是高风险人群的标志物，而不是因果关系危险因素，但我们建议在赎回第一个处方后的时期内进行系统的风险评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号