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首页> 外文期刊>Nordic journal of psychiatry. >Clozapine treatment and discontinuation in Iceland: A national longitudinal study using electronic patient records
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Clozapine treatment and discontinuation in Iceland: A national longitudinal study using electronic patient records

机译：冰岛的氯氮平治疗和停用：使用电子病历的全国性纵向研究

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Background: Clozapine is the only drug approved for treatment-resistant schizophrenia. There is evidence that clozapine is underutilized. Aims: To evaluate the initiation and discontinuation of clozapine at Landspitali University Hospital in Iceland and the prevalence of antipsychotic polypharmacy in clozapine-treated patients. Methods: The study is a part of an ongoing longitudinal study of schizophrenia in Iceland. We identified 201 patients on clozapine or who have been on clozapine by using a keyword search in the electronic health records and by reviewing their medical records. Results: Mean age at first treatment with clozapine was 37.8 years. Mean follow-up period on clozapine was 11 years. After 20 years of treatment 71.2% of patients were still on clozapine. After one year of treatment 84.4% of patients were still receiving clozapine treatment. We estimate that 11.4% of patients with schizophrenia in Iceland are taking clozapine and that 16% have been treated with clozapine at some point. Polypharmacy is common, since nearly 2/3, 65.6%, of patients taking clozapine use at least one other antipsychotic and 16.9% are also receiving depot injections. Conclusions: We need to increase the awareness of psychiatrists in Iceland with regard to treatment with clozapine, since only about half of the estimated population of patients with treatment-resistant schizophrenia in Iceland have ever been treated with clozapine. Nearly two thirds of patients who are prescribed clozapine in Iceland remain on it long-term.
机译：背景：氯氮平是唯一被批准用于治疗抗精神分裂症的药物。有证据表明氯氮平未得到充分利用。目的：评估在冰岛Landspitali大学医院开始和停用氯氮平的情况，以及氯氮平治疗患者中抗精神病药房的流行情况。方法：该研究是正在进行的冰岛精神分裂症纵向研究的一部分。通过使用电子健康记录中的关键字搜索并查看他们的病历，我们确定了201名氯氮平患者或氯氮平患者。结果：首次接受氯氮平治疗的平均年龄为37.8岁。氯氮平的平均随访期为11年。治疗20年后，仍有71.2％的患者使用氯氮平。治疗一年后，仍有84.4％的患者接受氯氮平治疗。我们估计，冰岛有11.4％的精神分裂症患者正在服用氯氮平，并且在某些时候已经用氯氮平治疗了16％。多元药房很常见，因为将近2 / 3、65.6％的服用氯氮平的患者至少使用了另一种抗精神病药，还有16.9％的患者也接受了大剂量注射。结论：我们需要提高冰岛的精神科医生对氯氮平治疗的认识，因为估计只有约一半的冰岛抗精神分裂症患者接受过氯氮平治疗。冰岛有将近三分之二的服用氯氮平的患者可以长期服用。

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